Beneficial effects of αB-crystallin in spinal cord contusion injury
Klopstein, Armelle (Universitat Autònoma de Barcelona. Institut de Neurociències)
Santos Nogueira, Eva (Universitat Autònoma de Barcelona. Institut de Neurociències)
Francos Quijorna, Isaac (Universitat Autònoma de Barcelona. Institut de Neurociències)
Redensek, Adriana (McGill University Health Centre. Center for Research in Neuroscience)
David, Samuel (McGill University Health Centre. Center for Research in Neuroscience)
Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
López Vales, Rubén (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date:	2012
Abstract:	αB-crystallin is a member of the heat shock protein family that exerts cell protection under several stress-related conditions. Recent studies have revealed that αB-crystallin plays a beneficial role in a mouse model of multiple sclerosis, brain ischemia, and Alexander disease. Whether αB-crystallin plays a role in modulating the secondary damage after CNS trauma is not known. We report here that αB-crystallin mediates protective effects after spinal cord injury. The levels of αB-crystallin are reduced in spinal cord tissue following contusion lesion. In addition, administration of recombinant human αB-crystallin for the first week after contusion injury leads to sustained improvement in locomotor skills and amelioration of secondary tissue damage. We also provide evidence that recombinant human αB-crystallin modulates the inflammatory response in the injured spinal cord, leading to increased infiltration of granulocytes and reduced recruitment of inflammatory macrophages. Furthermore, the delivery of recombinant human αB-crystallin promotes greater locomotor recovery even when the treatment is initiated 6 h after spinal cord injury. Our findings suggest that administration of recombinant human αB-crystallin may be a good therapeutic approach for treating acute spinal cord injury, for which there is currently no effective treatment.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials i que es distribueixin sota la mateixa llicència que regula l'obra original. Cal que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Medul·la espinal ; Ferides, lesions, etc. ; Tractament ; αB-Crystallin ; Spinal cord injury ; αB-cristal·lina
Published in:	The journal of neuroscience, Vol. 32 No. 42 (October 2012) , p. 14478-14488, ISSN 1529-2401

DOI: 10.1523/JNEUROSCI.0923-12.2012
PMID: 23077034

11 p, 4.1 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles