Effects of a post-weaning cafeteria diet in young rats : metabolic syndrome, reduced activity and low anxiety-like behaviour
F. Lalanza, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències)
Caimari, Antoni (Centre Tecnològic de Nutrició i Salut (Reus))
Bas, Josep M. del (Centre Tecnològic de Nutrició i Salut (Reus))
Torregrosa, Daniel (Universitat Autònoma de Barcelona. Institut de Neurociències)
Cigarroa, Igor (Universitat Autònoma de Barcelona. Institut de Neurociències)
Pallàs, Mercè (Universitat de Barcelona. Institut de Biomedicina)
Capdevila Ortís, Lluís (Universitat Autònoma de Barcelona. Laboratori de Psicologia de l'Esport)
Arola, Lluís (Centre Tecnològic de Nutrició i Salut (Reus))
Escorihuela, Rosa M. (Universitat Autònoma de Barcelona. Institut de Neurociències)

Fecha:	2014
Resumen:	Among adolescents, overweight, obesity and metabolic syndrome are rapidly increasing in recent years as a consequence of unhealthy palatable diets. Animal models of diet-induced obesity have been developed, but little is known about the behavioural patterns produced by the consumption of such diets. The aim of the present study was to determine the behavioural and biochemical effects of a cafeteria diet fed to juvenile male and female rats, as well as to evaluate the possible recovery from these effects by administering standard feeding during the last week of the study. Two groups of male and female rats were fed with either a standard chow diet (ST) or a cafeteria (CAF) diet from weaning and for 8 weeks. A third group of males (CAF withdrawal) was fed with the CAF diet for 7 weeks and the ST in the 8th week. Both males and females developed metabolic syndrome as a consequence of the CAF feeding, showing overweight, higher adiposity and liver weight, increased plasma levels of glucose, insulin and triglycerides, as well as insulin resistance, in comparison with their respective controls. The CAF diet reduced motor activity in all behavioural tests, enhanced exploration, reduced anxiety-like behaviour and increased social interaction; this last effect was more pronounced in females than in males. When compared to animals only fed with a CAF diet, CAF withdrawal increased anxiety in the open field, slightly decreased body weight, and completely recovered the liver weight, insulin sensitivity and the standard levels of glucose, insulin and triglycerides in plasma. In conclusion, a CAF diet fed to young animals for 8 weeks induced obesity and metabolic syndrome, and produced robust behavioural changes in young adult rats, whereas CAF withdrawal in the last week modestly increased anxiety, reversed the metabolic alterations and partially reduced overweight.
Ayudas:	European Commission 244995 Ministerio de Ciencia e Innovación PSI2011-29807-C02-02 Ministerio de Economía y Competitividad ACC1O/TECRD11-1-0012
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Diet ; Dieta ; Obesity ; Obesitat ; Overweight ; Sobrepès ; Metabolic syndrome ; Síndrome metabòlica ; Anxiety ; Ansietat
Publicado en:	PloS one, Vol. 9 Issue 1 (January 2014) , p. e85049, ISSN 1932-6203

DOI: 10.1371/journal.pone.0085049
PMID: 24482678

9 p, 784.1 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Neurociències (INc)
Artículos > Artículos de investigación
Artículos > Artículos publicados