Imaging the microanatomy of astrocyte-T-cell interactions in immune-mediated inflammation
Barcia, Carlos (Hospital General Universitario de Valencia)
Mitxitorena, Izaskun (Universitat Autònoma de Barcelona. Institut de Neurociències)
Carrillo-de Sauvage, Maria A. (Institut d'Imagerie Biomédicale)
Gallego, José Maria (Hospital General Universitario de Valencia)
Perez-Vallés, Ana (Consorci Hospital General Universitari (Valencia). Departament de Patologia)
Barcia, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències)

Fecha:	2013
Resumen:	The role of astrocytes in the immune-mediated inflammatory response in the brain is more prominent than previously thought. Astrocytes become reactive in response to neuro-inflammatory stimuli through multiple pathways, contributing significantly to the machinery that modifies the parenchymal environment. In particular, astrocytic signaling induces the establishment of critical relationships with infiltrating blood cells, such as lymphocytes, which is a fundamental process for an effective immune response. The interaction between astrocytes and T-cells involves complex modifications to both cell types, which undergo micro-anatomical changes and the redistribution of their binding and secretory domains. These modifications are critical for different immunological responses, such as for the effectiveness of the T-cell response, for the specific infiltration of these cells and their homing in the brain parenchyma, and for their correct apposition with antigen-presenting cells (APCs) to form immunological synapses (ISs). In this article, we review the current knowledge of the interactions between T-cells and astrocytes in the context of immune-mediated inflammation in the brain, based on the micro-anatomical imaging of these appositions by high-resolution confocal microscopy and three-dimensional rendering. The study of these dynamic interactions using detailed technical approaches contributes to understanding the function of astrocytes ininflammatory responses and paves the way for new therapeutic strategies.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Astròcits ; Cèl·lules T ; Citoquines ; Quimioquines ; Gliomes ; Resposta immunitària ; Astrocyte ; T-cell ; Immunological synapse ; Sinapsi immunològica ; Infiltration ; Infiltració ; Cytokines ; Chemokines ; Glioma ; Immune response
Publicado en:	Frontiers in cellular neuroscience, Vol. 7 (April 2013) , p. 1-10, ISSN 1662-5102

DOI: 10.3389/fncel.2013.00058
PMID: 23641198

10 p, 2.3 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Neurociències (INc)
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