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The ins and outs of the BCCAo model for chronic hypoperfusion : a multimodal and longitudinal MRI approach
Soria, Guadalupe (Institut d’Investigacions Biomèdiques August Pi i Sunyer)
Tudela, Raúl (Institut d’Investigacions Biomèdiques August Pi i Sunyer)
Márquez-Martín, Ana (Universitat Autònoma de Barcelona. Institut de Neurociències)
Camón, Lluïsa (Institut d’Investigacions Biomèdiques de Barcelona)
Batallé, Dafnis (Institut d’Investigacions Biomediques August Pi i Sunyer)
Muñoz Moreno, Emma (Institut d’Investigacions Biomediques August Pi i Sunyer)
Eixarch, Elisenda (Institut d’Investigacions Biomediques August Pi i Sunyer)
Puig, Josep (Institut d'Investigació Biomèdica de Girona)
Pedraza, Salvador (Institut d'Investigació Biomèdica de Girona)
Vila Calsina, Elisabet (Universitat Autònoma de Barcelona. Institut de Neurociències)
Prats-Galino, Alberto (Universitat de Barcelona. Laboratori de Neuroanatomia Quirúrgica)
Planas, Anna M. (Institut d’Investigacions Biomèdiques de Barcelona)

Date: 2013
Abstract: Cerebral hypoperfusion induced by bilateral common carotid artery occlusion (BCCAo) in rodents has been proposed as an experimental model of white matter damage and vascular dementia. However, the histopathological and behavioral alterations reported in this model are variable and a full characterization of the dynamic alterations is not available. Here we implemented a longitudinal multimodal magnetic resonance imaging (MRI) design, including timeof-flight angiography, high resolution T1-weighted images, T2 relaxometry mapping, diffusion tensor imaging, and cerebral blood flow measurements up to 12 weeks after BCCAo or sham-operation in Wistar rats. Changes in MRI were related to behavioral performance in executive function tasks and histopathological alterations in the same animals. MRI frequently (70%) showed various degrees of acute ischemic lesions, ranging from very small to large subcortical infarctions. Independently, delayed MRI changes were also apparent. The patterns of MRI alterations were related to either ischemic necrosis or gliosis. Progressive microstructural changes revealed by diffusion tensor imaging in white matter were confirmed by observation of myelinated fiber degeneration, including severe optic tract degeneration. The latter interfered with the visually cued learning paradigms used to test executive functions. Independently of brain damage, BCCAo induced progressive arteriogenesis in the vertebrobasilar tree, a process that was associated with blood flow recovery after 12 weeks. The structural alterations found in the basilar artery were compatible with compensatory adaptive changes driven by shear stress. In summary, BCCAo in rats induces specific signatures in multimodal MRI that are compatible with various types of histological lesion and with marked adaptive arteriogenesis.
Note: Número d'acord de subvenció EC/FP7/201024
Note: Número d'acord de subvenció MINECO/ERANET-NEURON/PRI-PIMNEU-2011-1340
Note: Número d'acord de subvenció ISCIII/PS09/00527
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Malalties cerebrovasculars ; Hipoperfusió
Published in: PLoS One, Vol. 8 Issue 9 (September 2013) , p. 74631-18, ISSN 1932-6203

DOI: 10.1371/journal.pone.0074631
PMID: 24058609

18 p, 2.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles

 Record created 2014-10-15, last modified 2018-11-11

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