Lipoic acid treatment after brain injury : study of the glial reaction
Rocamonde, Brenda (Universidad CEU Cardenal Herrera. Facultad de Ciencias de la Salud)
Paradells, Sara (Universidad CEU Cardenal Herrera. Facultad de Ciencias de la Salud)
Barcia, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències)
García Esparza, Ángeles (Universidad CEU Cardenal Herrera. Facultad de Ciencias de la Salud)

Date:	2013
Abstract:	After trauma brain injury, oxidative substances released to the medium provoke an enlargement of the initial lesion, increasing glial cell activation and, occasionally, an influx of immune cells into the central nervous system, developing the secondary damage. In response to these stimuli, microglia are activated to perform upregulation of intracellular enzymes and cell surface markers to propagate the immune response and phagocytosis of cellular debris. The phagocytosis of debris and dead cells is essential to limit the inflammatory reaction and potentially prevent extension of the damage to noninjured regions. Lipoic acid has been reported as a neuroprotectant by acting as an antioxidant and anti-inflammatory agent. Furthermore, angiogenic effect promoted by lipoic acid has been recently shown by our group as a crucial process for neural regeneration after brain injury. In this work, we focus our attention on the lipoic acid effect on astroglial and microglial response after brain injury.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Brain injury ; Glial reaction ; Lipoic acid
Published in:	Clinical and Developmental Immunology, Vol. 2013, article ID 521939 (2013), ISSN 1740-2530

DOI: 10.1155/2013/521939
PMID: 24302959

9 p, 5.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles