Web of Science: 17 cites, Scopus: 17 cites, Google Scholar: cites,
Sex-dependent effects of an early life treatment in rats that increases maternal care : vulnerability or resilience?
Fuentes García, Silvia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Daviu Abant, Núria (Universitat Autònoma de Barcelona. Institut de Neurociències)
Gagliano, Humberto Antonio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Garrido, Pedro (Universitat Autònoma de Barcelona. Institut de Neurociències)
Zelena, Dora (Magyar Tudományos Akadémia. Kísérleti Orvostudományi Kutatóintézetének)
Monasterio, Nela (Universitat Autònoma de Barcelona. Institut de Neurociències)
Armario García, Antonio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Nadal i Alemany, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències)

Data: 2014
Resum: Early life stress (ELS) in rodents has profound long-term effects that are partially mediated by changes in maternal care. ELS not only induces “detrimental” effects in adulthood, increasing psychopathology, but also promotes resilience to further stressors. In Long-Evans rats, we evaluated a combination of two procedures as a model of ELS: restriction of bedding during the first post-natal days and exposure to a “substitute” mother. The maternal care of biological and “substitute” mothers was measured. The male and female offspring were evaluated during adulthood in several contexts. Anxiety was measured by the elevated plus-maze (EPM), acoustic startle response (ASR) and forced swim test (FST). In other group of animals, novelty-seeking was measured (activity in an inescapable novel environment, preference for novel environments and exploration of novel objects). Plasmatic ACTH and corticosterone in basal conditions and in response to stress were also measured. Cognitive impulsivity was assessed by a delay-discounting paradigm, and impulsive action, attention and compulsive-like behavior by a five choice serial reaction time task (5CSRTT). ELS decreased pup body weight and increased the care of the biological mother; however, the “substitute” mother did not exhibit overt maltreatment. A mixture of “detrimental” and “beneficial” effects was shown. In the 5CSRTT, attention was impaired in both genders, and in females, ELS increased compulsive-like behavior. Novel object exploration was only increased by ELS in males, but the preference for novel spaces decreased in both genders. Baseline anxiety (EPM and ASR) and recognition memory were not affected. Unexpectedly, ELS decreased the ACTH response to novelty and swim stress and increased active coping in the FST in both genders. Cognitive impulsivity was decreased only in females, but impulsive action was not affected. The enhancement in maternal care may “buffer” the effects of ELS in a context-dependent manner.
Nota: Altres ajuts: Del MICINN, el PTA2010-3472-I; FPU AP-2007-02841
Nota: Número d'acord de subvenció MINECO/SAF2011-28313
Nota: Número d'acord de subvenció ISCIII/RD12/0028/0014
Nota: Número d'acord de subvenció AGAUR/2009/SGR-16
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Matèria: Stress ; Maternal behavior ; HPA axis ; Impulsivity ; Anxiety ; Novelty-seeking ; Sex
Publicat a: Frontiers in Behavioral Neuroscience, Vol. 8, Num. 56 (February 2014) , p. 1-22, ISSN 1662-5153

DOI: 10.3389/fnbeh.2014.00056
PMID: 24616673

22 p, 2.4 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Neurociències (INc)
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 Registre creat el 2015-01-26, darrera modificació el 2018-11-10

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