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Traumatic brain injury in late adolescent rats : effects on adulthood memory and anxiety
Amorós-Aguilar, Laura (Universitat Autònoma de Barcelona. Institut de Neurociències)
Portell Cortés, Isabel (Universitat Autònoma de Barcelona. Institut de Neurociències)
Costa Miserachs, David (Universitat Autònoma de Barcelona. Institut de Neurociències)
Torras Garcia, Meritxell (Universitat Autònoma de Barcelona. Institut de Neurociències)
Coll, Margalida (Coll Andreu) (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date: 2015
Abstract: The consequences of traumatic brain injury (TBI) sustained during late adolescence (7 weeks-old) on spontaneous object recognition memory and on anxiety-like behaviors in the elevated plus maze were tested in rats during adulthood. Testing took place at two different post injury times, in separate groups: three and six weeks, when animals were 10 and 13 weeks old, respectively. The rats were either submitted to controlled cortical impact injury, an experimental model of focal TBI with contusion, or were shamoperated. TBI animals failed to remember the familiar object and had a significantly lower performance than sham-operated animals, indicating memory disruption, when the retention delay was 24 h, but not when it was 3 h. TBI did not have any significant effect on the main anxiety-related behaviors, but it reduced time in the central platform of the elevated plus maze. The effects of TBI on memory and on anxiety-like behaviors were similar at the two post injury times. In both TBI and sham-operated groups, animals tested six weeks after surgery had lower anxiety-related indices than those tested at three weeks, an effect that might be indicative of reduced anxiety levels with increasing age. In summary, focal TBI with contusion sustained during late adolescence led to object recognition memory deficits in a 24-h test during adulthood, but did not have a major impact on anxiety-like behaviors. Memory deficits persisted for at least six weeks after injury, indicating that spontaneous modifications of these functional disturbances did not take place along this time span.
Note: This article may not exactly replicate the final version published in the APA journal. It is not the copy of record.
Rights: Tots els drets reservats
Language: Anglès.
Document: article ; recerca ; acceptedVersion
Subject: Traumatic brain injury ; Controlled cortical impact ; Object recognition memory ; Emotional reactivity ; Rat
Published in: Behavioral neuroscience, ISSN 0735-7044

DOI: 10.1037/bne0000046


Post-print
37 p, 312.9 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles

 Record created 2015-03-20, last modified 2019-08-30



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