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Dyslipidemia and chronic inflammation markers are correlated with telomere length shortening in Cushing's syndrome
Aulinas Masó, Anna (Institut d'Investigacions Biomèdiques Sant Pau)
Ramírez de Haro, Ma. José (María José) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Barahona Constanzo, María José (Hospital Mútua de Terrassa. Departament d'Endocrinologia)
Valassi, Elena (Institut d'Investigacions Biomèdiques Sant Pau)
Resmini, Eugenia (Institut d'Investigacions Biomèdiques Sant Pau)
Mato, Eugènia (Institut d'Investigacions Biomèdiques Sant Pau)
Santos, Alicia (Institut d'Investigacions Biomèdiques Sant Pau)
Crespo, Iris (Institut d'Investigacions Biomèdiques Sant Pau)
Bell, Olga (IInstitut d'Investigacions Biomèdiques Sant Pau)
Surrallés i Calonge, Jordi (Universitat Autonoma de Barcelona. Departament de Genètica i de Microbiologia)
Webb, S. M. q (Susan M.), 1952- (Institut d'Investigacions Biomèdiques Sant Pau)

Date: 2015
Abstract: INTRODUCTION: Cushing's syndrome (CS) increases cardiovascular risk (CVR) and adipocytokine imbalance, associated with an increased inflammatory state. Telomere length (TL) shortening is a novel CVR marker, associated with inflammation biomarkers. We hypothesized that inflammatory state and higher CVR in CS might be related to TL shortening, as observed in premature aging. - AIM: to evaluate relationships between TL, CVR and inflammation markers in CS. - METHODS: in a cross-sectional study, 77 patients with CS (14 males, 59 pituitary-, 17 adrenal- and 1 ectopic-origin; 21 active disease) and 77 age-, gender-, smoking-matched controls were included. Total white blood cell TL was measured by TRF-Southern technique. Clinical data and blood samples were collected (lipids, adrenal function, glucose). Adiponectin, interleukin-6 (IL6) and C-reactive protein (CRP) were available in a subgroup of patients (n=32). Correlations between TL and clinical features were examined and multiple linear regression analysis was performed to investigate potential predictors of TL. - RESULTS: dyslipidemic CS had shorter TL than non-dyslipidemic subjects (7328±1274 vs 7957±1137 bp, p<0. 05). After adjustment for age and body mass index, cured and active CS dyslipidemic patients had shorter TL than non-dyslipidemic CS (cured: 7187±1309 vs 7868±1104; active: 7203±1262 vs 8615±1056, respectively, p<0. 05). Total cholesterol and triglycerides negatively correlated with TL (r-0. 279 and -0. 259, respectively, p<0. 05), as well as CRP and IL6 (r-0. 412 and -0. 441, respectively, p<0. 05). No difference in TL according the presence of other individual CVR factors (hypertension, diabetes mellitus, obesity) were observed in CS or in the control group. Additional TL shortening was observed in dyslipidemic obese patients who were also hypertensive, compared to those with two or less CVR factors (6956±1280 vs 7860±1180, respectively, p<0. 001). Age and dyslipidemia were independent negative predictors of TL. -CONCLUSION :TL is shortened in dyslipidemic CS patients, further worse if hypertension and/or obesity coexist and is negatively correlated with increased inflammation markers. Increased lipids and a "low" grade inflammation may contribute to TL shortening and consequently to premature ageing and increased morbidity in CS.
Note: Número d'acord de subvenció ISCIII /PI11/00001
Note: Número d'acord de subvenció ISCIII /PI08/0302
Note: Número d'acord de subvenció AGAUR/2009/SGR-0489
Note: Número d'acord de subvenció AGAUR/2014/SGR-355
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Dyslipidemia ; Inflammation ; Cushing's Sundrome ; Telomere
Published in: PLoS one, Vol. 10, Issue 3 (March 2015) , p. e0120185., ISSN 1932-6203

DOI: 10.1371/journal.pone.0120185
PMID: 25799396

15 p, 857.4 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació Biomèdica Sant Pau
Articles > Research articles
Articles > Published articles

 Record created 2015-06-04, last modified 2018-09-06

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