Independent comparison study of six different electronic tongues applied for pharmaceutical analysis
Pein, Miriam (Heinrich-Heine-Universität Düsseldorf. Institut für Pharmazeutische Technologie und Biopharmazie)
Kirsanov, Dmitry (Sankt-Peterburgskiĭ gosudarstvennyĭ universitet. Institut khimii)
Ciosek, Patrycja (Politechnika Warszawska. Department of Microbioanalytics)
Valle Zafra, Manuel del (Universitat Autònoma de Barcelona. Departament de Química)
Yaroshenko, Irina (Sankt-Peterburgskiĭ gosudarstvennyĭ universitet. Institut khimii)
Wesoly, Malgorzata (Politechnika Warszawska. Department of Microbioanalytics)
Zabadaj, Marcin (Politechnika Warszawska. Department of Microbioanalytics)
González-Calabuig, Andreu (Universitat Autònoma de Barcelona. Departament de Química)
Wróblewski, Wojciech (Politechnika Warszawska. Department of Microbioanalytics)
Legin, Andrey (Sankt-Peterburgskiĭ gosudarstvennyĭ universitet. Institut khimii)

Date:	2015
Abstract:	Electronic tongue technology based on arrays of cross-sensitive chemical sensors and chemometric data processing has attracted a lot of researchers' attention through the last years. Several so far reported applications dealing with pharmaceutical related tasks employed different e-tongue systems to address different objectives. In this situation, it is hard to judge on the benefits and drawbacks of particular e-tongue implementations for R&D in pharmaceutics. The objective of this study was to compare the performance of six different e-tongues applied to the same set of pharmaceutical samples. For this purpose, two commercially available systems (from Insent and AlphaMOS) and four laboratory prototype systems (two potentiometric systems from Warsaw operating in flow and static modes, one potentiometric system from St. Petersburg, one voltammetric system from Barcelona) were employed. The sample set addressed in the study comprised nine different formulations based on caffeine citrate, lactose monohydrate, maltodextrine, saccharin sodium and citric acid in various combinations. To provide for the fair and unbiased comparison, samples were evaluated under blind conditions and data processing from all the systems was performed in a uniform way. Different mathematical methods were applied to judge on similarity of the e-tongues response from the samples. These were principal component analysis (PCA), RV' matrix correlation coefficients and Tuckeŕs congruency coefficients.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Electronic tongue ; Comparison ; Blind conditions ; Taste masking
Published in:	Journal of pharmaceutical and biomedical analysis, Vol. 114 (Oct. 2015) , p. 321-329, ISSN 0731-7085

DOI: 10.1016/j.jpba.2015.05.026

Post-print 22 p, 1.6 MB

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