Web of Science: 23 citas, Scopus: 21 citas, Google Scholar: citas,
Type 2 diabetes-associated carotid plaque burden is increased in patients with retinopathy compared to those without retinopathy.
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Traveset, Alicia (Hospital Universitari Arnau de Vilanova (Lleida, Catalunya))
Rubinat, Esther (Hospital Universitari Arnau de Vilanova (Lleida, Catalunya))
Ortega, Emilio (Fundació Clínic. Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Alcubierre, Nuria (Institut de Recerca Biomedica de Lleida)
Sanahuja, Jordi (Hospital Universitari Arnau de Vilanova (Lleida, Catalunya))
Hernández, Marta (Hospital Universitari Arnau de Vilanova (Lleida, Catalunya))
Betriu, Àngels (Hospital Universitari Arnau de Vilanova (Lleida, Catalunya))
Jurjo, Carmen (Hospital Universitari Arnau de Vilanova (Lleida, Catalunya))
Fernández, Elvira (Hospital Universitari Arnau de Vilanova (Lleida, Catalunya))
Mauricio Puente, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Fecha: 2015
Resumen: BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality among subjects with type 2 diabetes (T2D), and diabetic retinopathy (DR) has been associated with an increased risk for CVD. The present study was designed to test the concept that T2D patients with DR, but without previous cardiovascular (CV) events and with normal renal function, have an increased atherosclerotic burden compared with patients without DR. METHODS: A cross-sectional study was performed using patients with normal renal function (estimated glomerular filtration rate (eGFR) >60 ml/min) and without previous CV events. A total of 312 patients (men, 51%; mean age, 57 yrs; age range 40-75 yrs) were included in the study; 153 (49%) of the patients had DR. B-mode carotid ultrasound imaging was performed for all of the study subjects to measure the carotid intima-media thickness (cIMT) and carotid plaques in the common carotid artery (CCA), bifurcation and internal carotid artery (ICA). RESULTS: The percentage of carotid plaques in T2D patients with DR was higher than in T2D patients without DR (68% vs. 52. 2%, p = 0. 0045), and patients with DR had a higher prevalence of ≥2 carotid plaques (44. 4% vs. 21. 4%; p < 0. 0001). No differences were observed in the cIMT measured at different carotid regions between the patients with or without DR. Using multivariate logistic regression (adjustment for major risk factors for atherosclerosis), DR was independently associated with mean-internal cIMT (p = 0. 0176), with the presence of carotid plaques (p = 0. 0366) and with carotid plaque burden (≥2 plaques; p < 0. 0001). CONCLUSIONS: The present study shows that DR in T2D patients without CVD and with normal renal function is associated with a higher atherosclerotic burden (presence and number of plaques) in the carotid arteries. These patients may be at a higher risk for future CV events; therefore, an ultrasound examination of the carotid arteries should be considered in patients with DR for more careful and individualised CV assessment and follow-up.
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Materia: Type 2 diabetes ; Cardiovascular disease ; Retinopathy ; Carotid plaque
Publicado en: Cardiovascular diabetology, Vol. 14, Núm. 33 (March 2015) , ISSN 1475-2840

DOI: 10.1186/s12933-015-0196-1
PMID: 25856787


9 p, 393.0 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Artículos > Artículos de investigación
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 Registro creado el 2016-07-25, última modificación el 2019-09-30



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