Web of Science: 2 citations, Scopus: 3 citations, Google Scholar: citations
Lack of Postprandial Peak in Brain-Derived Neurotrophic Factor in Adults with PraderWilli Syndrome
Bueno, Marta (Hospital Universitari Arnau de Vilanova)
Esteba i Castillo, Susanna (Parc Hospitalari Martí i Julià (Girona, Catalunya))
Novell, Ramon (Parc Hospitalari Martí i Julià (Girona, Catalunya))
Giménez-Palop, Olga (Corporació Sanitària Parc Taulí (Sabadell, Catalunya))
Coronas, Ramon (Corporació Sanitària Parc Taulí (Sabadell, Catalunya))
Gabau, Elisabeth (Corporació Sanitària Parc Taulí (Sabadell, Catalunya))
Corripio Collado, Raquel (Corporació Sanitària Parc Taulí (Sabadell, Catalunya))
Baena Díez, Neus (Corporació Sanitària Parc Taulí (Sabadell, Catalunya))
Viñas-Jornet, Marina (Corporació Sanitària Parc Taulí (Sabadell, Catalunya))
Guitart Feliubadaló, Miriam (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Torrents-Rodas, David (Parc Hospitalari Martí i Julià (Girona, Catalunya))
Deus Yela, Juan (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Pujol Nuez, Jesús (Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM))
Rigla Cros, Mercedes (Corporació Sanitària Parc Taulí (Sabadell, Catalunya))
Caixàs i Pedragós, Assumpta, dir (Universitat Autònoma de Barcelona. Departament de Medicina)

Date: 2016
Abstract: Context: Prader-Willi syndrome (PWS) is characterized by severe hyperphagia. Brain-derived neurotrophic factor (BDNF) and leptin are reciprocally involved in energy homeostasis. Objectives: To analyze the role of BDNF and leptin in satiety in genetic subtypes of PWS. Design: Experimental study. Setting: University hospital. Subjects: 90 adults: 30 PWS patients; 30 age-sex-BMI-matched obese controls; and 30 age-sex-matched lean controls. Interventions: Subjects ingested a liquid meal after fasting ≥10 hours. Main Outcome Measures: Leptin and BDNF levels in plasma extracted before ingestion and 30’, 60’, and 120’ after ingestion. Hunger, measured on a 100-point visual analogue scale before ingestion and 60’ and 120’ after ingestion. Results: Fasting BDNF levels were lower in PWS than in controls (p = 0. 05). Postprandially, PWS patients showed only a truncated early peak in BDNF, and their BDNF levels at 60' and 120' were lower compared with lean controls (p<0. 05). Leptin was higher in PWS patients than in controls at all time points (p<0. 001). PWS patients were hungrier than controls before and after eating. The probability of being hungry was associated with baseline BDNF levels: every 50-unit increment in BDNF decreased the odds of being hungry by 22% (OR: 0. 78, 95%CI: 0. 65–0. 94). In uniparental disomy, the odds of being hungry decreased by 66% (OR: 0. 34, 90%CI: 0. 13–0. 9). Postprandial leptin patterns did no differ among genetic subtypes. Conclusions: Low baseline BDNF levels and lack of postprandial peak may contribute to persistent hunger after meals. Uniparental disomy is the genetic subtype of PWS least affected by these factors.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Prader-Willi syndrome ; Leptin ; Obesity ; Insulin ; Body mass index ; Homeostasis ; Childhood obesity ; Growth hormone
Published in: PLoS one, Vol. 11 Núm. 9 (September 2016) , p. 1-15, ISSN 1932-6203

DOI: 10.1371/journal.pone.0163468
PMID: 27685845


15 p, 1.8 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2017-02-28, last modified 2018-07-25



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