Web of Science: 8 cites, Scopus: 8 cites, Google Scholar: cites,
Spatial and Temporal Phylogeny of Border Disease Virus in Pyrenean Chamois (Rupicapra p. pyrenaica)
Luzzago, Camilla
Ebranati, Erika
Cabezón Ponsoda, Óscar (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Fernández-Sirera, Laura (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Lavín González, Santiago (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Rosell, Rosa (Fundació Centre de Recerca en Sanitat Animal)
Veo, Carla
Rossi, Luca
Cavallero, Serena
Lanfranchi, Paolo
Marco Sánchez, Ignasi (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Zehender, Gianguglielmo

Data: 2016
Resum: Border disease virus (BDV) affects a wide range of ruminants worldwide, mainly domestic sheep and goat. Since 2001 several outbreaks of disease associated to BDV infection have been described in Pyrenean chamois (Rupicapra pyrenaica pyrenaica) in Spain, France and Andorra. In order to reconstruct the most probable places of origin and pathways of dispersion of BDV among Pyrenean chamois, a phylogenetic analysis of 95 BDV 5'untranslated sequences has been performed on chamois and domestic ungulates, including novel sequences and retrieved from public databases, using a Bayesian Markov Chain Monte Carlo method. Discrete and continuous space phylogeography have been applied on chamois sequences dataset, using centroid positions and latitude and longitude coordinates of the animals, respectively. The estimated mean evolutionary rate of BDV sequences was 2. 9×10−3 subs/site/year (95% HPD: 1. 5–4. 6×10−3). All the Pyrenean chamois isolates clustered in a unique highly significant clade, that originated from BDV-4a ovine clade. The introduction from sheep (dated back to the early 90s) generated a founder effect on the chamois population and the most probable place of origin of Pyrenean chamois BDV was estimated at coordinates 42. 42 N and 1. 9 E. The pathways of virus dispersion showed two main routes: the first started on the early 90s of the past century with a westward direction and the second arise in Central Pyrenees. The virus spread westward for more than 125 km and southward for about 50km and the estimated epidemic diffusion rate was about 13. 1 km/year (95% HPD 5. 2–21. 4 km/year). The strong spatial structure, with strains from a single locality segregating together in homogeneous groups, and the significant pathways of viral dispersion among the areas, allowed to reconstruct both events of infection in a single area and of migrations, occurring between neighboring areas.
Nota: Número d'acord de subvenció PRIN/2010P7LFW4
Nota: Número d'acord de subvenció CGL2006/11518/BOS
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Matèria: Phylogeography ; Phylogenetic analysis ; Sequence databases ; Andorra ; Sequence analysis ; Sheep ; Domestic animals ; Spain
Publicat a: PLoS one, Vol. 11 Num. 12 (December 2016) , p. 1-17, ISSN 1932-6203

DOI: 10.1371/journal.pone.0168232
PMID: 28033381


17 p, 1.5 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Centre de Recerca en Sanitat Animal (CReSA-IRTA)
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 Registre creat el 2017-02-28, darrera modificació el 2019-07-21



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