Web of Science: 8 cites, Scopus: 9 cites, Google Scholar: cites,
Follow-Up Genotoxic Study : Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill
Kristjánsdóttir, Kristín Hildur (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Templado, C. (Cristina) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Zock, Jan-Paul (Centre de Recerca en Epidemiologia Ambiental)
Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Pozo Rodríguez, Francisco (Hospital Universitario 12 de Octubre (Madrid). Departamento de Medicina Respiratoria)
Francès Reig, Alexandra (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Monyarch Gros, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Rodríguez-Trigo, Gema (Hospital Clínico San Carlos (Madrid). Departamento de Medicina Respiratoria)
Rodriguez-Rodriguez, Emma (Complexo Hospitalario Universitario A Coruña. Departamento de Medicina Respiratoria)
Souto, Ana (Complexo Hospitalario Universitario A Coruña. Departamento de Medicina Respiratoria)
Gómez, Federico P. (Hospital Clínic i Provincial de Barcelona. Departament de Medicina Respiratòria)
Antó i Boqué, Josep Maria (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Barberà i Mir, Joan Albert (Hospital Clínic i Provincial de Barcelona. Departament de Medicina Respiratòria)
Fuster i Marquès, Carme (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)

Data: 2015
Resum: Background: The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown. Objective: To realize a follow-up genotoxic study to detect whether the chromosome damage persisted six years after exposure to the oil. Design: Follow-up study. Setting: Fishermen cooperatives in coastal villages. Participants: Local fishermen who were highly exposed (n = 52) and non-exposed (n = 23) to oil seven years after the spill. Measurements: Chromosome damage in circulating lymphocytes. Results: Chromosome damage in exposed individuals persists six years after oil exposure, with a similar incidence than those previously detected four years before. A surprising increase in chromosome damage in non-exposed individual was found six years after Prestige spill vs. those detected two years after the exposure. Limitations: The sample size and the possibility of some kind of selection bias should be considered. Genotoxic results cannot be extrapolated to the approximately 300,000 individuals who participated occasionally in clean-up tasks. Conclusion: The persistence of chromosome damage detected in exposed individuals six years after oil exposure seems to indicate that the cells of the bone marrow are affected. A surprising increase in chromosome damage in non-exposed individuals detected in the follow-up study suggests an indirect exposition of these individuals to some oil compounds or to other toxic agents during the last four years. More long-term studies are needed to confirm the presence of chromosome damage in exposed and non-exposed fishermen due to the association between increased chromosomal damage and increased risk of cancer. Understanding and detecting chromosome damage is important for detecting cancer in its early stages. The present work is the first follow-up cytogenetic study carried out in lymphocytes to determine genotoxic damage evolution between two and six years after oil exposure in same individuals.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Matèria: Oils ; Chromosome structure and function ; Translocations ; Oil spills ; Biomarkers ; Cytogenetics ; Lymphocytes ; Metaphase
Publicat a: PLoS one, Vol. 10, Num. 7 (July 2015) , p. 1-11, ISSN 1932-6203

DOI: 10.1371/journal.pone.0132413
PMID: 26221948


11 p, 523.3 KB

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