The Progress of Therapeutic Vaccination with Regard to Tuberculosis
Cardona, Pere-Joan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Date:	2016
Abstract:	A major problem with tuberculosis (TB) control is the long duration of drug therapy-both for latent and for active TB. Therapeutic vaccination has been postulated to improve this situation, and to this end there are several candidates already in clinical phases of development. These candidates follow two main designs, namely bacilli-directed therapy based on inactivated -whole or -fragmented bacillus (Mycobacterium w and RUTI) or fusion proteins that integrate non-replicating bacilli -related antigens (H56 vaccine), and host-directed therapy to reduce the tissue destruction. The administration of inactivated Mycobacterium vaccae prevents the "Koch phenomenon" response, and oral administration of heat-killed Mycobacterium manresensis prevents excessive neutrophilic infiltration of the lesions. This review also tries to explain the success of Mycobacterium tuberculosis by reviewing its evolution from infection to disease, and highlights the lack of a definitive understanding of the natural history of TB pathology and the need to improve our knowledge on TB immunology and pathogenesis.
Grants:	Instituto de Salud Carlos III FEDER/PI11/01702 Instituto de Salud Carlos III FEDER/PI14/01038
Note:	Ajudes rebudes: Departament de Salut de la Generalitat de Catalunya; projecte CIBER CRP-T; Plan Nacional I+D+I
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Vacunes antituberculoses ; H56 ; Mycobacterium indicus pranii ; Mycobacterium manresensis ; Mycobacterium tuberculosis ; Mycobacterium vaccae ; Mycobacterium w ; Neutrophils ; Vaccines
Published in:	Frontiers in microbiology, Vol. 7 Núm. 11536 (September 2016) , ISSN 1664-302X

DOI: 10.3389/fmicb.2016.01536
PMID: 27733848

16 p, 4.7 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles