Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies
Lord, Phillip (Newcastle University. School of Computing Science)
Spiering, Rachel (Newcastle University. Institute of Cellular Medicine)
Aguillon, Juan C. (Universidad de Chile. Instituto de Ciencias Biomédicas (ICBM))
Anderson, Amy E. (Newcastle University. Institute of Cellular Medicine)
Appel, Silke (University of Bergen. Broegelmann Research Laboratory)
Benítez Ribas, Daniel (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Brinke, Anja ten (Sanquin Research (Amsterdam))
Broere, Femke (Utrecht University)
Cools, Nathalie (University of Antwerp. Vaccine & Infectious Disease Institute)
Cuturi, Maria Cristina (Center for Research in Transplantation and Immunology (Nantes, França))
Diboll, Julie (Newcastle University. Institute of Cellular Medicine)
Geissler, Edward K. (University Hospital Regensburg. Department of Surgery)
Giannoukakis, Nick (Institute of Cellular Therapeutics (Pittsburgh, Estats Units d'Amèrica))
Gregori, Silvia (San Raffaele Telethon Institute for Gene Therapy (Milà, Itàlia))
Ham, S. Marieke van (Sanquin Research (Amsterdam))
Lattimer, Staci (Newcastle University. School of Computing Science)
Marshall, Lindsay (Newcastle University. School of Computing Science)
Harry, Rachel A. (Newcastle University. Institute of Cellular Medicine)
Hutchinson, James A. (University Hospital Regensburg. Department of Surgery)
Isaacs, John D. (Newcastle University. Institute of Cellular Medicine)
Joosten, Irma (Radboud University Medical Centre)
Kooten, Cees van (Leiden University Medical Centre)
López Díaz de Cerio, Ascensión (Clínica Universidad de Navarra)
Nikolic, Tatjana (Leiden University Medical Centre)
Oral, Haluk Barbaros (Uludag University. Faculty of Medicine)
Sofronic Milosavljevic, Ljiljana (University of Belgrade. Institute for the Application of Nuclear Energy)
Ritter, Thomas (National University of Ireland)
Riquelme, Paloma (University Hospital Regensburg. Department of Surgery)
Thomson, Angus W. (University of Pittsburgh School of Medicine)
Trucco, Massimo (Institute of Cellular Therapeutics (Pittsburgh, Estats Units d'Amèrica))
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Hilkens, Catharien M. U. (Newcastle University. Institute of Cellular Medicine)

Date:	2016
Abstract:	Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation. The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from different studies; thus constituting a major hurdle for the development of standardised tolAPC therapeutic products. Here we describe an initiative by members of the tolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC products transparent. In this way, MITAP constitutes a first but important step towards the production of standardised and reproducible tolAPC for clinical application.
Note:	Altres ajuts: COST/AFACTT/BM1305
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Antigen-presenting cells ; Autoimmune disease ; Cell therapy ; Minimum information model ; Regulatory macrophages ; Reporting guidelines ; Tolerogenic dendritic cells ; Transplantation
Published in:	PeerJ, Vol. 4 (August 2016) , p. e2300, ISSN 2167-8359

DOI: 10.7717/peerj.2300
PMID: 27635311

14 p, 516.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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