Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential
Qualai, Jamal (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Li, Lin-Xi (University of Arkansas for Medical Sciences)
Cantero, Jon (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Tarrats, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fernández Sanmartin, Marco Antonio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sumoy, Lauro (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
Rodolosse, Annie (Institute for Research in Biomedicine (IRB Barcelona))
McSorley, Stephen J. (University of California)
Genescà Ferrer, Meritxell (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)

Fecha:	2016
Resumen:	CD11c is an α integrin classically employed to define myeloid dendritic cells. Although there is little information about CD11c expression on human T cells, mouse models have shown an association of CD11c expression with functionally relevant T cell subsets. In the context of genital tract infection, we have previously observed increased expression of CD11c in circulating T cells from mice and women. Microarray analyses of activated effector T cells expressing CD11c derived from naïve mice demonstrated enrichment for natural killer (NK) associated genes. Here we find that murine CD11c+ T cells analyzed by flow cytometry display markers associated with non-conventional T cell subsets, including γδ T cells and invariant natural killer T (iNKT) cells. However, in women, only γδ T cells and CD8+ T cells were enriched within the CD11c fraction of blood and cervical tissue. These CD11c+ cells were highly activated and had greater interferon (IFN)-γ secretory capacity than CD11c- T cells. Furthermore, circulating CD11c+ T cells were associated with the expression of multiple adhesion molecules in women, suggesting that these cells have high tissue homing potential. These data suggest that CD11c expression distinguishes a population of circulating T cells during bacterial infection with innate capacity and mucosal homing potential.
Nota:	Ajudes rebudes: Marie Curie Career Integration Grant; Dexeus Foundation for Women's Health Research; i Contratos Ramón y Cajal
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cèl·lules dendrítiques ; Sistema immunològic ; VIH (Virus) ; CD11c ; Myeloid dendritic cells
Publicado en:	PloS one, Vol. 11 Núm. 4 (April 2016) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0154253
PMID: 27119555

22 p, 7.0 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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