Web of Science: 13 cites, Scopus: 13 cites, Google Scholar: cites,
Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential
Qualai, Jamal (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Li, Lin-Xi (University of Arkansas for Medical Sciences)
Cantero, Jon (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Tarrats, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fernández Sanmartín, Marco Antonio (Institut Germans Trias i Pujol)
Sumoy, Lauro (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
Rodolosse, Annie (Institute for Research in Biomedicine (IRB Barcelona))
McSorley, Stephen J. (University of California)
Genescà, Meritxell (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)

Data: 2016
Resum: CD11c is an α integrin classically employed to define myeloid dendritic cells. Although there is little information about CD11c expression on human T cells, mouse models have shown an association of CD11c expression with functionally relevant T cell subsets. In the context of genital tract infection, we have previously observed increased expression of CD11c in circulating T cells from mice and women. Microarray analyses of activated effector T cells expressing CD11c derived from naïve mice demonstrated enrichment for natural killer (NK) associated genes. Here we find that murine CD11c+ T cells analyzed by flow cytometry display markers associated with non-conventional T cell subsets, including γδ T cells and invariant natural killer T (iNKT) cells. However, in women, only γδ T cells and CD8+ T cells were enriched within the CD11c fraction of blood and cervical tissue. These CD11c+ cells were highly activated and had greater interferon (IFN)-γ secretory capacity than CD11c- T cells. Furthermore, circulating CD11c+ T cells were associated with the expression of multiple adhesion molecules in women, suggesting that these cells have high tissue homing potential. These data suggest that CD11c expression distinguishes a population of circulating T cells during bacterial infection with innate capacity and mucosal homing potential.
Nota: Ajudes rebudes: Marie Curie Career Integration Grant; Dexeus Foundation for Women's Health Research; i Contratos Ramón y Cajal
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Matèria: Cèl·lules dendrítiques ; Sistema immunològic ; VIH (Virus) ; CD11c ; Myeloid dendritic cells
Publicat a: PloS one, Vol. 11 Núm. 4 (April 2016) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0154253
PMID: 27119555


22 p, 7.0 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2017-05-22, darrera modificació el 2018-10-21



   Favorit i Compartir