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Página principal > Artículos > Artículos publicados > Engineering building blocks for self-assembling protein nanoparticles |
Fecha: | 2010 |
Resumen: | Like natural viruses, manmade protein cages for drug delivery are to be ideally formed by repetitive subunits with self-assembling properties, mimicking viral functions and molecular organization. Naturally formed nanostructures (such as viruses, flagella or simpler protein oligomers) can be engineered to acquire specific traits of interest in biomedicine, for instance through the addition of cell targeting agents for desired biodistribution and specific delivery of associated drugs. However, fully artificial constructs would be highly desirable regarding finest tuning and adaptation to precise therapeutic purposes. Although engineering of protein assembling is still in its infancy, arising principles and promising strategies of protein manipulation point out the rational construction of nanoscale protein cages as a feasible concept, reachable through conventional recombinant DNA technologies and microbial protein production. |
Ayudas: | European Commission 980409 Ministerio de Educación y Ciencia FISS/PS09/00165 Ministerio de Educación y Ciencia BFU2010-17450 Ministerio de Educación y Ciencia ACI2009-0919 Ministerio de Educación y Ciencia IT2009-0021 Agència de Gestió d'Ajuts Universitaris i de Recerca 2005/SGR-00956 |
Nota: | Altres ajuts: MECN/EUI2008-03610 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Publicado en: | Microbial cell factories, Vol. 9, Issue 101 (Dec. 2010) , ISSN 1475-2859 |
4 p, 264.4 KB |