Web of Science: 42 cites, Scopus: 53 cites, Google Scholar: cites,
Behavioural fever is a synergic signal amplifying the innate immune response
Boltaña Harms, Sebastian (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Rey i Planellas, Sònia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Roher Armentia, Nerea (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Vargas, Reynaldo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Huerta, Mario (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Huntingford, Felicity A. (University of Glasgow)
Goetz, Frederick William (Northwest Fisheries Science Centre (Seattle, USA))
Moore, Janice (Colorado State University. Biology Department)
Garcia Valtanen, Pablo (Universidad Miguel Hernández de Elche)
Estepa, Amparo (Universidad Miguel Hernandez de Elche)
MacKenzie, Simon A. (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")

Data: 2013
Resum: Behavioural fever, defined as an acute change in thermal preference driven by pathogen recognition, has been reported in a variety of invertebrates and ectothermic vertebrates. It has been suggested, but so far not confirmed, that such changes in thermal regime favour the immune response and thus promote survival. Here, we show that zebrafish display behavioural fever that acts to promote extensive and highly specific temperature-dependent changes in the brain transcriptome. The observed coupling of the immune response to fever acts at the gene–environment level to promote a robust, highly specific time-dependent anti-viral response that, under viral infection, increases survival. Fish that are not offered a choice of temperatures and that therefore cannot express behavioural fever show decreased survival under viral challenge. This phenomenon provides an underlying explanation for the varied functional responses observed during systemic fever. Given the effects of behavioural fever on survival and the fact that it exists across considerable phylogenetic space, such immunity–environment interactions are likely to be under strong positive selection.
Nota: Número d'acord de subvenció MICINN/AGL2011-28921-C03-01
Nota: Número d'acord de subvenció MICINN/CSD2007-0002
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Matèria: Behavioural fever ; Anti-viral response ; Gene–environment interaction
Publicat a: Proceedings of the Royal Society B: Biological Sciences, Vol. 280 (Sep. 2013) , art. 20131381, ISSN 1471-2954

PMID: 23843398
DOI: 10.1098/rspb.2013.1381

11 p, 1.2 MB

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