Hypertension in autosomal-dominant polycystic kidney disease (ADPKD)
Sans-Atxer, Laia (Hospital del Mar (Barcelona, Catalunya))
Torra Balcells, Roser (Universitat Autònoma de Barcelona. Departament de Medicina)
Fernandez-Llama, Patricia (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2013
Abstract:	Cardiovascular (CV) complications are the major cause of death in autosomal-dominant polycystic kidney disease (ADPKD) patients. Hypertension is common in these patients even before the onset of renal insufficiency. Blood pressure (BP) elevation is a key factor in patient outcome, mainly owing to the high prevalence of target organ damage together with a poor renal prognosis when BP is increased. Many factors have been implicated in the pathogenesis of hypertension, including the renin-angiotensin-aldosterone system (RAAS) stimulation. Polycystin deficiency may also contribute to hypertension because of its potential role in regulating the vascular tone. Early diagnosis and treatment of hypertension improve the CV and renal complications of this population. Ambulatory BP monitoring is recommended for prompt diagnosis of hypertension. CV risk assessment is mandatory. Even though a nonpharmacological approach should not be neglected, RAAS inhibitors are the cornerstone of hypertension treatment. Calcium channel blockers (CCBs) should be avoided unless resistant hypertension is present. The BP should be <140/90 mmHg in all ADPKD patients and a more intensive control (<135/85 mmHg) should be pursued as soon as microalbuminuria or left ventricle hypertrophy is present.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-1116
Note:	Altres ajuts: FISPI10-01261
Note:	Altres ajuts: FISPI12-01523
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Ambulatory blood pressure monitoring ; Blood pressure profile ; Cardiovascular risk ; Polycystic kidney disease ; Renal size
Published in:	Clinical Kidney Journal, Vol. 6 (april 2013) , p. 457-463, ISSN 2048-8513

DOI: 10.1093/ckj/sft031
PMID: 26064509

7 p, 173.5 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles