Evaluation of Rapid Progressors in HIV Infection as an Extreme Phenotype
Olson, Ashley D. (University College London. Medical Research Council Clinical Trials Unit (United Kingdom))
Guiguet, Marguerite (Université Pierre et Marie Curie (France))
Zangerle, Robert (Innsbruck Medical University (Austria))
Gill, John (University of Calgary (Canada))
Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron)
Lodi, Sara (Instituto de Salud Carlos III)
Ghosn, Jade (CHU Bicêtre. Service de Médecine Interne et Maladies Infectieuses (France))
Dorrucci, Maria (Istituto Superiore di Sanità)
Johnson, Anne (University College London. Institute of Epidemiology and Health Care (United Kingdom))
Sannes, Mette (Ulleval University Hospital (Norway))
Moreno, Santiago (Hospital Universitario Ramón y Cajal (Madrid))
Porter, Kholoud (University College London. Medical Research Council Clinical Trials Unit (United Kingdom))
Universitat Autònoma de Barcelona

Fecha:	2014
Resumen:	Supplemental Digital Content is Available in the Text. Rapid CD4 cell loss represents an HIV phenotype used to identify causal variants of accelerated disease progression. The optimal rate and threshold for identifying this extreme phenotype in recently infected individuals is unclear. Using a cohort of patients with known dates of HIV-1 seroconversion (SC), CASCADE (Concerted Action on SeroConversion on AIDS and Death in Europe), we identified proportions experiencing nadir CD4 cell levels within 1 year of SC, and assessed their mean AIDS-free survival time at 10-year follow-up and hazard of AIDS/death, compared with those whose CD4 remained.
Ayudas:	European Commission 260694
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	HIV ; Rare phenotype ; Disease progression ; Genetics
Publicado en:	Journal of acquired immune deficiency syndromes (1999), Vol. 67, Issue 1 (September 2014) , p. 15-21, ISSN 1944-7884

DOI: 10.1097/QAI.0000000000000240
PMID: 24872130

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