HIV-1 Capture and Transmission by Dendritic Cells : The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Lorizate, Maier (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular)
McLaren, Paul J. (Lausanne University Hospital)
Telenti, Amalio (Lausanne University Hospital)
Kräusslich, Hans-Georg (Universitätsklinikum Heidelberg. Department of Infectious Diseases, Virology)
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats)
Universitat Autònoma de Barcelona
Date: |
2014 |
Abstract: |
Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans -infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans -infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans -infection. |
Grants: |
Ministerio de Ciencia e Innovación SAF2010-21224
|
Note: |
Altres ajuts: Work in JMP group is supported by the Spanish AIDS network "Red Temática Cooperativa de Investigación en SIDA" (RD06/0006) |
Rights: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Language: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Published in: |
PLOS pathogens, Vol. 10 (july 2014) , ISSN 1553-7374 |
DOI: 10.1371/journal.ppat.1004146
PMID: 25033082
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Record created 2018-01-29, last modified 2024-03-04