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HIV-1 Capture and Transmission by Dendritic Cells : The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Lorizate, Maier (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular)
McLaren, Paul J. (Lausanne University Hospital)
Telenti, Amalio (Lausanne University Hospital)
Kräusslich, Hans-Georg (Universitätsklinikum Heidelberg. Department of Infectious Diseases, Virology)
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats)
Universitat Autònoma de Barcelona

Date: 2014
Abstract: Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans -infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans -infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans -infection.
Grants: Ministerio de Ciencia e Innovación SAF2010-21224
Note: Altres ajuts: Work in JMP group is supported by the Spanish AIDS network "Red Temática Cooperativa de Investigación en SIDA" (RD06/0006)
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: Article ; recerca ; Versió publicada
Published in: PLOS pathogens, Vol. 10 (july 2014) , ISSN 1553-7374

DOI: 10.1371/journal.ppat.1004146
PMID: 25033082


9 p, 915.2 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles

 Record created 2018-01-29, last modified 2024-03-04



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