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Interspecific hybridization as a genomic stressor inducing mobilization of transposable elements in Drosophila
Guerreiro, Maria Pilar García (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Data: 2014
Resum: Transposable elements (TEs) are DNA sequences able to be mobilized in host genomes. They are currently recognized as the major mutation inducers because of their insertion in the target, their effect on neighboring regions, or their ectopic recombination. A large number of factors including chemical and physical factors as well as intraspecific crosses have traditionally been identified as inducers of transposition. Besides environmental factors, interspecific crosses have also been proposed as promoters of transposition of particular TEs in plants and different animals. Our previous published work includes a genome-wide survey with the set of genomic TEs and shows that interspecific hybridization between the species Drosophila buzzatii and Drosophila koepferae induces genomic instability by transposition bursts. A high percentage of this instability corresponds to TEs belonging to classes I and II. The detailed study of three TEs (Osvaldo, Helena, and Galileo), representative of the different TE families, shows an increase of transposition in hybrids compared with parental species, that varies depending on the element. This study suggests ample variation in TE regulation mechanisms and the question is why this variation occurs. Interspecific hybridization is a genomic stressor that disrupts the stability of TEs probably contributing to a relaxation of the mechanisms controlling TEs in the Drosophila genome. In this commentary paper we will discuss these results and the molecular mechanisms that could explain these increases of transposition rates observed in interspecific Drosophila hybrids.
Ajuts: Ministerio de Ciencia e Innovación CGL2009-12912-C03-01
Ministerio de Ciencia e Innovación CGL2010-15395
Nota: Altres ajuts: I want to thank grants 2009SGR 636 from Generalitat de Catalunya to the Grup de Biologia Evolutiva.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Drosophila ; Transposable elements ; Interspecific hybridization ; Transposition ; Genomic instability ; Epigenetic factors
Publicat a: Mobile Genetic Elements, Vol. 4 (august 2014) , ISSN 2159-256X

DOI: 10.4161/mge.34394
PMID: 25136509

4 p, 512.0 KB

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