Neuroimaging and psychophysiological investigation of the link between anxiety, enhanced affective reactivity and interoception in people with joint hypermobility
Mallorquí-Bagué, Núria (Grup Quirónsalud (Barcelona, Catalunya))
Garfinkel, Sarah N. (University of Sussex. Sackler Centre for Consciousness Science)
Engels, Miriam (Maastricht University. Faculty of Psychology and Neuroscience)
Eccles, Jessica A. (Sussex Partnership NHS Foundation Trust)
Pailhez, Guillem (Institut Hospital del Mar d'Investigacions Mèdiques)
Bulbena Vilarrasa, Antonio (Institut Hospital del Mar d'Investigacions Mèdiques)
Critchley, Hugo D. (University of Sussex. Sackler Centre for Consciousness Science)
Universitat Autònoma de Barcelona

Data:	2014
Resum:	Objective: Anxiety is associated with increased physiological reactivity and also increased "interoceptive" sensitivity to such changes in internal bodily arousal. Joint hypermobility, an expression of a common variation in the connective tissue protein collagen, is increasingly recognized as a risk factor to anxiety and related disorders. This study explored the link between anxiety, interoceptive sensitivity and hypermobility in a sub-clinical population using neuroimaging and psychophysiological evaluation. Methods: Thirty-six healthy volunteers undertook interoceptive sensitivity tests, a clinical examination for hypermobility and completed validated questionnaire measures of state anxiety and body awareness tendency. Nineteen participants also performed an emotional processing paradigm during functional neuroimaging. Results: We confirmed a significant relationship between state anxiety score and joint hypermobility. Interoceptive sensitivity mediated the relationship between state anxiety and hypermobility. Hypermobile, compared to non-hypermobile, participants displayed heightened neural reactivity to sad and angry scenes within brain regions implicated in anxious feeling states, notably insular cortex. Conclusions: Our findings highlight the dependence of anxiety state on bodily context, and increase our understanding of the mechanisms through which vulnerability to anxiety disorders arises in people bearing a common variant of collagen.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Anxiety ; Functional magnetic resonance imaging (fMRI) ; Interoception ; Emotion ; Joint hypermobility ; Psychology
Publicat a:	Frontiers in psychology, Vol. 5 (october 2014) , ISSN 1664-1078

DOI: 10.3389/fpsyg.2014.01162
PMID: 25352818

8 p, 1.3 MB

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