Nodular Mucinosis of the Breast in a Male : Reassessment of Diagnostic Criteria and Proposal for Its Classification as a Soft Tissue Tumor in the Myofibroblastoma and Spindle Cell Lipoma Spectrum
Fernández-Figueras, Maria Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Kazakov, Dmitry V. (Charles University Medical Faculty Hospital. c Sikl Department of Pathology)
López Martos, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ojanguren, Isabel (Institut Germans Trias i Pujol)
Vila, Jordi (b Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ariza, Aurelio (Institut Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Date:	2014
Abstract:	Nodular mucinosis of the breast (NMB) is a rare entity with only a few cases described in the literature, most of them in young girls. All cases are located in the nipple and areolar area and microscopically consist of a multinodular myxoid mesenchymal proliferation. Bands of sclerotic collagen containing preexisting breast ducts and abundant vascularization are other features typical of NMB. No relation to Carney complex has been reported, and an indolent behavior is the rule in all patients. We present a case of NMB occurring in the nipple of a 46-year-old man and analyze the clinicopathological features of the other cases of NMB reported in the English literature, concluding that two of them most likely correspond to trauma-induced cutaneous focal mucinosis of the mammary areola. Finally, we review diagnostic criteria for NMB and elaborate an ontogenetic hypothesis based on both its morphological resemblance to myofibroblastoma and its immunohistochemical profile.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	article ; recerca ; publishedVersion
Subject:	Breast ; Nipple ; Mucinosis ; Myofibroblastoma
Published in:	Dermatopathology, Vol. 1 (july 2014) , p. 47-54, ISSN 2296-3529

DOI: 10.1159/000364859
PMID: 27047922

8 p, 1.2 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles