Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults : a randomized controlled trial
Trabal, Joan (Hospital Clínic i Provincial de Barcelona)
Forga-Martel, Maria (Hospital Clínic i Provincial de Barcelona)
Leyes, Pere (Hospital Clínic i Provincial de Barcelona)
Torres, Ferran (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Rubio, Jordi (Residencia Ballesol Almogavers, Grupo Ballesol, Barcelona)
Prieto, Esther (Fundació Amiba (Badalona, Catalunya))
Farran-Codina, Andreu (Universitat de Barcelona. Departament de Nutrició, Ciències de l'Alimentació i Gastronomia)

Data:	2015
Resum:	To assess the effect of free leucine supplementation combined with resistance training versus resistance training only on muscle strength and functional status in older adults. This was a randomized, double-blind, placebo-controlled, parallel study with two intervention groups. Thirty older adults were randomly assigned to receive either 10 g leucine/day (leucine group [LG], n=15) or a placebo (control group [CG], n=15), plus resistance training over a 12-week period. Maximal overcoming isometric leg strength, functional status, nutritional status, body composition, health-related quality of life, depression, and dietary intake were assessed at 4 and 12 weeks. Missing data at 12 weeks were handled using mixed models for repeated measurements for data imputation. Twenty-four subjects completed the 4-week assessment and eleven completed the 12-week intervention. Clinically significant gains were found in isometric leg strength at both assessment time points. Analysis of the effect size also showed how participants in LG outperformed those in CG for chair stands and the timed up and go test. No significant changes were observed for the rest of the outcomes. Our combined analysis showed moderate changes in isometric leg muscle strength and certain components of functional status. The magnitude of changes found on these outcomes should be qualified as a positive effect of the concomitant intervention.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Aged ; Elderly ; Strength training ; Amino acid ; Functionality
Publicat a:	Clinical Interventions in Aging, Vol. 10 (april 2015) , p. 713-723, ISSN 1178-1998

DOI: 10.2147/CIA.S75271
PMID: 25926725

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