A post-partum single-dose TDF/FTC tail does not prevent the selection of NNRTI resistance in women receiving pre-partum ZDV and intrapartum single-dose nevirapine to prevent mother-to- child HIV-1 transmission
Samuel, Reshmi (University of KwaZulu-Natal)
Paredes, Roger (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Parboosing, Raveen (University of KwaZulu-Natal)
Moodley, Pravi (University of KwaZulu-Natal)
Singh, Lavanya (University of KwaZulu-Natal)
Naidoo, Anneta (University of KwaZulu-Natal)
Gordon, Michelle (HIV Pathogenesis Laboratory, Nelson R. Mandela Medical School, University of KwaZulu-Natal)
Universitat Autònoma de Barcelona

Fecha:	2015
Resumen:	Although the rates of vertical transmission of HIV in the developing world have improved to around 3% in countries like South Africa, resistance to antiretrovirals (ARV) used in Prevention of Mother-to-Child transmission (pMTCT) strategies may thwart such outcomes and affect the efficacy of future ARV regimens in mothers and children. This study conducted in Durban, South Africa, between 2010 and 2013 found a high rate of nevirapine (NVP) resistance among women receiving Zidovudine (AZT) from 14 weeks gestation, single dose nevirapine (sd NVP) at the onset of labor and a single dose of coformulated Tenofovir/Emtricitabine (TDF/FTC) postpartum. Using Sanger sequencing, high and intermediate levels of nevirapine (NVP) resistance were detected in 15/44 (34%) and in 1/44 (2%) of women tested, respectively. Most subjects selected the K103N mutation (22% (10/45) of all patients and 66% (10/15) of those with high-level NVP resistance). Such rate of NVP resistance is comparable to studies where only sd NVP was used. In conclusion, a post-partum single-dose TDF/FTC tail does not prevent the selection of NNRTI resistance in women receiving pre-partum ZDV and intrapartum sd NVP to prevent mother-to-child HIV-1 transmission. J. Med. Virol. 87:1662-1667, 2015. © 2015 The Authors. Journal of Medical Virology published by Wiley Periodicals, Inc.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	HIV drug resistance ; Vertical transmission
Publicado en:	Journal of Medical Virology, Vol. 87 (may 2015) , p. 1662-1667, ISSN 1096-9071

DOI: 10.1002/jmv.24220
PMID: 25940687

6 p, 189.4 KB

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