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Genetic association study of coronary collateral circulation in patients with coronary artery disease using 22 single nucleotide polymorphisms corresponding to 10 genes involved in postischemic neovascularization
Duran, Joan (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental)
Olavarría, Pilar Sánchez (Departamento de Estadística, Facultad de Ciencias, Universidad de Valparaíso)
Mola, Marina (Neurovascular Research Group (NEUVAS), Parc de Recerca Biomèdica de Barcelona)
Götzens, Víctor (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental)
Carballo, Julio (Centre Cardiovascular Sant Jordi)
Pelegrina, Eva Martín (Centre Cardiovascular Sant Jordi)
Petit, Màrius (Centre Cardiovascular Sant Jordi)
Abdul-Jawad Altisent, Omar (Department of Cardiology. Hospital Mútua de Terrassa)
Otaegui, Imanol (Hospital Universitari Vall d'Hebron)
del Blanco, Bruno García (Hospital Universitari Vall d'Hebron)
García-Dorado, David (Hospital Universitari Vall d'Hebron)
Reig, Josep (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques)
Cordero, Alex (Àrea Epigenetics and Cancer Biology Area, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL))
de Anta, Josep Maria (Departament de Patologia i Terapèutica Experimental. Universitat de Barcelona)

Fecha: 2015
Resumen: Collateral growth in patients with coronary artery disease (CAD) is highly heterogeneous. Although multiple factors are thought to play a role in collateral development, the contribution of genetic factors to coronary collateral circulation (CCC) is largely unknown. The goal of this study was to assess whether functional single nucleotide polymorphisms (SNPs) in genes involved in vascular growth are associated with CCC. 677 consecutive CAD patients were enrolled in the study and their CCC was assessed by the Rentrop method. 22 SNPs corresponding to 10 genes involved in postischemic neovascularization were genotyped and multivariate logistic regression models were adjusted using clinically relevant variables to estimate odds ratios and used to examine associations of allelic variants, genotypes and haplotypes with CCC. Statistical analysis showed that the HIF1A rs11549465 and rs2057482; VEGFA rs2010963, rs1570360, rs699947, rs3025039 and rs833061; KDR rs1870377, rs2305948 and rs2071559; CCL2 rs1024611, rs1024610, rs2857657 and rs2857654; NOS3 rs1799983; ICAM1 rs5498 and rs3093030; TGFB1 rs1800469; CD53 rs6679497; POSTN rs3829365 and rs1028728; and LGALS2 rs7291467 polymorphisms, as well as their haplotype combinations, were not associated with CCC (p < 0. 05). We could not validate in our cohort the association of the NOS3 rs1799983, HIF1A rs11549465, VEGFA rs2010963 and rs699947, and LGALS2 rs7291467 variants with CCC reported by other authors. A validated SNP-based genome-wide association study is required to identify polymorphisms influencing CCC.
Nota: Altres ajuts: Fundació La Marató de TV3 07 (project 080810); Universitat de Barcelona (project ACESBELL 08)
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès
Documento: article ; recerca ; publishedVersion
Materia: Collateral circulation ; Arteriogenesis ; Postischemic neovascularization ; Single nucleotide polymorphism ; Genetic association study
Publicado en: BMC Cardiovascular disorders, Vol. 15 (may 2015) , ISSN 1471-2261

DOI: 10.1186/s12872-015-0027-z
PMID: 25959001


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