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| Pàgina inicial > Articles > Articles publicats > Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder |
(FIDMAG Germanes Hospitalàries Research Foundation) (FIDMAG Germanes Hospitalàries Research Foundation) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (FIDMAG Germanes Hospitalàries Research Foundation) (FIDMAG Germanes Hospitalàries Research Foundation) (FIDMAG Germanes Hospitalàries Research Foundation) (FIDMAG Germanes Hospitalàries Research Foundation) (Hospital Benito Menni) (Institut d'Investigacions Biomèdiques August Pi i Sunyer)| Data: | 2015 |
| Resum: | Brain structural changes in schizoaffective disorder, and how far they resemble those seen in schizophrenia and bipolar disorder, have only been studied to a limited extent. Forty-five patients meeting - and criteria for schizoaffective disorder, groups of patients with 45 matched schizophrenia and bipolar disorder, and 45 matched healthy controls were examined using voxel-based morphometry (). Analyses comparing each patient group with the healthy control subjects found that the patients with schizoaffective disorder and the patients with schizophrenia showed widespread and overlapping areas of significant volume reduction, but the patients with bipolar disorder did not. A subsequent analysis compared the combined group of patients with the controls followed by extraction of clusters. In regions where the patients differed significantly from the controls, no significant differences in mean volume between patients with schizoaffective disorder and patients with schizophrenia in any of five regions of volume reduction were found, but mean volumes in the patients with bipolar disorder were significantly smaller in three of five. The findings provide evidence that, in terms of structural gray matter brain abnormality, schizoaffective disorder resembles schizophrenia more than bipolar disorder. |
| Ajuts: | Instituto de Salud Carlos III PI10/01058 Instituto de Salud Carlos III PI10/02622 Instituto de Salud Carlos III PI09/1893 Instituto de Salud Carlos III PI07/1278 Instituto de Salud Carlos III PI05/1874 Instituto de Salud Carlos III CP10/00596 Instituto de Salud Carlos III CP07/00048 Instituto de Salud Carlos III CP06/0359 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-1022 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-211 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Neuroimaging ; Schizoaffective disorder ; Schizo-phrenia ; Bipolar disorder ; Voxel-based morphometry |
| Publicat a: | Acta psychiatrica Scandinavica, Vol. 133, issue 1 (Jan. 2016) , p. 23-33, ISSN 1600-0447 |
