Web of Science: 978 citations, Scopus: 962 citations, Google Scholar: citations,
Biological properties of extracellular vesicles and their physiological functions
Yáñez-Mó, María (Universidad Autónoma de Madrid. Departamento de Biología Molecular)
Siljander, Pia R.-M. (University of Helsinki. Department of Biosciences)
Andreu, Zoraida (Universidad Autónoma de Madrid. Departamento de Biología Molecular)
Zavec, Apolonija Bedina (National Institute of Chemistry (Ljubljana))
Borràs, Francesc E. (Institut Germans Trias i Pujol)
Buzas, Edit I. (Semmelweis University. Department of Genetics, Cell- and Immunobiology)
Buzas, Krisztina (University of Szeged. Faculty of Dentistry)
Casal, Enriqueta (CIC bioGUNE)
Cappello, Francesco (Euro-Mediterranean Institute of Science and Technology (Palermo))
Carvalho, Joana (Institute of Molecular Pathology and Immunology of the University of Porto)
Colás, Eva (Vall d'Hebron Institut de Recerca)
Cordeiro da Silva, Anabela (University of Porto. Department of Biological Sciences,)
Fais, Stefano (National Institute of Health. Department of Therapeutic Research and Medicines Evaluation (Rome))
Falcon Perez, Juan M. (CIC bioGUNE)
Ghobrial, Irene M. (Dana-Farber Cancer Institute)
Giebel, Bernd (University Hospital Essen. Institute for Transfusion Medicine)
Gimona, Mario (Universitätsklinikum. Department of Blood Group Serology and Transfusion Medicine (Salzburg))
Graner, Michael (University of Colorado Denver. Department of Neurosurgery)
Gursel, Ihsan (Bilkent University. Department of Molecular Biology and Genetics)
Gursel, Mayda (Middle East Technical University. Department of Biological Sciences)
Heegaard, Niels H. H. (Statens Serum Institut. Department of Clinical Biochemistry, Immunology & Genetics)
Hendrix, An (Ghent University Hospital. Department of Radiation Oncology and Experimental Cancer Research)
Kierulf, Peter (Oslo University Hospital. Department of Medical Biochemistry)
Kokubun, Katsutoshi (Dana-Farber Cancer Institute)
Kosanovic, Maja (University of Belgrade. Institute for the Application of Nuclear Energy)
Kralj-Iglic, Veronika (University of Ljubljana. Faculty of Health Sciences)
Krämer-Albers, Eva-Maria (University of Mainz. Molecular Cell Biology and Focus Program Translational Neurosciences)
Laitinen, Saara (Finnish Red Cross Blood Service)
Lässer, Cecilia (University of Gothenburg. Institute of Medicine at the Sahlgrenska Academy)
Lener, Thomas (Universitätsklinikum. Department of Blood Group Serology and Transfusion Medicine)
Ligeti, Erzsébet (Semmelweis University. Department of Physiology)
Linē, Aija (Latvian Biomedical Research and Study Centre)
Lipps, Georg (University of Applied Sciences and Arts Northwestern Switzerland. Institute of Chemistry and Bioanalytics)
Llorente, Alicia (Oslo University Hospital – The Norwegian Radium Hospital. Institute for Cancer Research)
Lötvall, Jan (University of Gothenburg. Institute of Medicine at the Sahlgrenska Academy)
Manček-Keber, Mateja (EN→FIST Centre of Excellence (Ljubljana))
Marcilla, Antonio (Universitat de Valencia. Departamento de Biología Celular y Parasitologia)
Mittelbrunn, Maria (Centro Nacional de Investigaciones Cardiovasculares (Madrid))
Nazarenko, Irina (University of Freiburg. Institute for Environmental Health Sciences and Hospital Infection Control Medical Center)
Nolte-'t Hoen, Esther N.M. (Utrecht University. Department of Biochemistry and Cell Biology)
Nyman, Tuula A. (University of Helsinki. Institute of Biotechnology)
O'Driscoll, Lorraine (Trinity College Dublin. School of Pharmacy and Pharmaceutical Sciences & Trinity Biomedical Sciences Institute)
Olivan, Mireia (Vall d'Hebron Institut de Recerca)
Oliveira, Carla (University of Porto. Department of Pathology and Oncology)
Pállinger, Éva (Semmelweis University. Department of Genetics, Cell- and Immunobiology)
del Portillo, Hernando A. (Institució Catalana de Recerca i Estudis Avançats)
Reventós, Jaume (Vall d'Hebron Institut de Recerca)
Rigau, Marina (Vall d'Hebron Institut de Recerca)
Rohde, Eva (Universitätsklinikum. Department of Blood Group Serology and Transfusion Medicine (Salzburg))
Sammar, Marei (ORT Braude College. Department of Biotechnology Engineering)
Sánchez-Madrid, Francisco (Hospital de la Princesa. Instituto de Investigaciones Sanitarias Princesa)
Santarém, N. (IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto)
Schallmoser, Katharina (Uniklinikum Salzburg. University Clinic of Blood Group Serology and Transfusion Medicine)
Ostenfeld, Marie Stampe (Aarhus University Hospital. Departmnet of Molecular Medicine)
Stoorvogel, Willem (Utrecht University. Department of Biochemistry and Cell Biology)
Stukelj, Roman (University of Ljubljana. Laboratory of Clinical Biophysics)
Van der Grein, Susanne G. (Utrecht University. Department of Biochemistry and Cell Biology)
Vasconcelos, M. Helena (University of Porto. Department of Biological Sciences)
Wauben, Marca H. M. (Utrecht University. Department of Biochemistry and Cell Biology)
De Wever, Olivier (Ghent University Hospital. Department of Radiation Oncology and Experimental Cancer Research)
Universitat Autònoma de Barcelona

Date: 2015
Abstract: In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.
Note: The authors wish to thank Dr R Simpson and Dr D Taylor for critical reading of the manuscript and acknowledge the Horizon 2020 European Cooperation in Science and Technology programme and its support of our European Network on Microvesicles and Exosomes in Health & Disease (ME-HaD; BM1202 www.cost.eu/COST_Actions/bmbs/Actions/BM1202).
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Extracellular vesicle ; Microvesicle ; Microparticle ; Exosome ; Physiology ; Prokaryote ; Eukaryote
Published in: Journal of extracellular vesicles, Vol. 4 (2015) , ISSN 2001-3078

PMID: 25979354
DOI: 10.3402/jev.v4.27066


60 p, 3.6 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2018-01-31, last modified 2019-01-25



   Favorit i Compartir