Non-Traditional Systemic Treatments for Diabetic Retinopathy : AnEvidence-Based Review
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron)
Ballarini, Stefania (Vifor Pharma/OM Pharma, Global Medical Affairs Infectious Disease/OTX)
Cunha-Vaz, José (Universidade de Coimbra)
Ji, Linong (Peking University. Department of Endocrinology and Metabolism)
Haller, Hermann (Hannover Medical School. Department of Nephrology and Hypertension)
Zimmet, Paul (Victor Smorgon Diabetes Centre)
Wong, Tien Y. (Singapore Eye Research Institute. National University of Singapore)
Universitat Autònoma de Barcelona

Data:	2015
Resum:	The rapid escalation in the global prevalence diabetes, with more than 30% being afflicted with diabetic retinopathy (DR), means it is likely that associated vision-threatening conditions will also rise substantially. This means that new therapeutic approaches need to be found that go beyond the current standards of diabetic care, and which are effective in the early stages of the disease. In recent decades several new pharmacological agents have been investigated for their effectiveness in preventing the appearance and progression of DR or in reversing DR; some with limited success while others appear promising. This up-to-date critical review of non-traditional systemic treatments for DR is based on the published evidence in MEDLINE spanning 1980-December 2014. It discusses a number of therapeutic options, paying particular attention to the mechanisms of action and the clinical evidence for the use of renin-angiotensin system blockade, fenofibrate and calcium dobesilate monohydrate in DR.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article de revisió ; Article ; Versió publicada
Matèria:	Calcium dobesilate ; Diabetic retinopathy ; Fenofibrate ; Renin-angiotensin system blockade
Publicat a:	Current medicinal chemistry, Vol. 22 (june 2015) , p. 2580-2589, ISSN 1875-533X

DOI: 10.2174/0929867322666150520095923
PMID: 25989912

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