Web of Science: 0 citas, Scopus: 0 citas, Google Scholar: citas,
Clinical intervals and diagnostic characteristics in a cohort of prostate cancer patients in Spain : a multicentre observational study
Bonfill Cosp, Xavier (Institut d'Investigació Biomèdica Sant Pau)
Martinez Zapata, María José (Universitat Autònoma de Barcelona)
Vernooij, Robin WM (Institut d'Investigació Biomèdica Sant Pau)
Sánchez, María José (Instituto de Investigación Biosanitaria de Granada)
Suárez Varela, María Morales (Universitat de Valencia. Departament de Medicina Preventiva)
de la Cruz, Javier (Hospital 12 de Octubre, Madrid)
Emparanza, José Ignacio (Hospital Universitario Donostia)
Ferrer, Montserrat (IMIM (Hospital del Mar Medical Research Institute))
Pijoán, José Ignacio (Unidad de Epidemiología Clínica y Soporte Metodológico, UICEC de BioCruces-SCReN, Barakaldo)
Ramos Goñi, Juan M. (Health Services Research on Chronic Patients Network (REDISSEC))
Palou, Joan (Institut d'Investigació Biomèdica Sant Pau)
Schmidt, Stefanie (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Abraira, Víctor (Unidad de Bioestadística Clínica, Hospital Universitario Ramón y Cajal)
Zamora, Javier (Unidad de Bioestadística Clínica, Hospital Universitario Ramón y Cajal)

Fecha: 2015
Resumen: Little is known about the healthcare process for patients with prostate cancer, mainly because hospital-based data are not routinely published. The main objective of this study was to determine the clinical characteristics of prostate cancer patients, the, diagnostic process and the factors that might influence intervals from consultation to diagnosis and from diagnosis to treatment. We conducted a multicentre, cohort study in seven hospitals in Spain. Patients' characteristics and diagnostic and therapeutic variables were obtained from hospital records and patients' structured interviews from October 2010 to September 2011. We used a multilevel logistic regression model to examine the association between patient care intervals and various variables influencing these intervals (age, BMI, educational level, ECOG, first specialist consultation, tumour stage, PSA, Gleason score, and presence of symptoms) and calculated the odds ratio (OR) and the interquartile range (IQR). To estimate the random inter-hospital variability, we used the median odds ratio (MOR). 470 patients with prostate cancer were included. Mean age was 67. 8 (SD: 7. 6) years and 75. 4 % were physically active. Tumour size was classified as T1 in 41. 0 % and as T2 in 40 % of patients, their median Gleason score was 6. 0 (IQR:1. 0), and 36. 1 % had low risk cancer according to the D'Amico classification. The median interval between first consultation and diagnosis was 89 days (IQR:123. 5) with no statistically significant variability between centres. Presence of symptoms was associated with a significantly longer interval between first consultation and diagnosis than no symptoms (OR:1. 93, 95%CI 1. 29–2. 89). The median time between diagnosis and first treatment (therapeutic interval) was 75. 0 days (IQR:78. 0) and significant variability between centres was found (MOR:2. 16, 95%CI 1. 45–4. 87). This interval was shorter in patients with a high PSA value (p = 0. 012) and a high Gleason score (p = 0. 026). Most incident prostate cancer patients in Spain are diagnosed at an early stage of an adenocarcinoma. The period to complete the diagnostic process is approximately three months whereas the therapeutic intervals vary among centres and are shorter for patients with a worse prognosis. The presence of prostatic symptoms, PSA level, and Gleason score influence all the clinical intervals differently.
Nota: Número d'acord de subvenció ISCIII/FIS/PS09/01204
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Materia: Prostatic neoplasms ; Male urogenital diseases ; Multicentre study ; Cohort study ; Prospective study
Publicado en: BMC Urology, Vol. 15 (july 2015) , ISSN 1471-2490

PMID: 26134117
DOI: 10.1186/s12894-015-0058-x


11 p, 409.0 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació Biomèdica Sant Pau
Artículos > Artículos de investigación
Artículos > Artículos publicados

 Registro creado el 2018-01-31, última modificación el 2019-09-17



   Favorit i Compartir