Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases?
Sánchez de Groot, Natalia (Laboratory of Molecular Biology. Medical Research Council)
Torrent Burgas, Marc (Laboratory of Molecular Biology. Medical Research Council)
Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular

Date:	2015
Abstract:	Systemic inflammation and infections are associated with neurodegenerative diseases. Unfortunately, the molecular bases of this link are still largely undiscovered. We, therefore, review how inflammatory processes can imbalance membrane homeostasis and theorize how this may have an effect on the aggregation behavior of the proteins implicated in such diseases. Specifically, we describe the processes that generate such imbalances at the molecular level, and try to understand how they affect protein folding and localization. Overall, current knowledge suggests that microglia pro-inflammatory mediators can generate membrane damage, which may have an impact in terms of triggering or accelerating disease manifestation.
Grants:	Ministerio de Economía y Competitividad RYC/2012-09999 Ministerio de Economía y Competitividad SAF/2014-56568-R European Commission 299105 European Commission 330352
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Protein aggregation ; Neurodegenerative disease ; Neuroinflammation ; Membrane ; Microglia
Published in:	Cellular and Molecular Life Sciences, Vol. 72, Issue 24 (December 2015) , p. 4795-4805, ISSN 1420-9071

DOI: 10.1007/s00018-015-2038-4
PMID: 26403788

11 p, 2.0 MB

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