Web of Science: 4 citations, Scopus: 4 citations, Google Scholar: citations,
Validity of the CR-POSSUM model in surgery for colorectal cancer in Spain (CCR-CARESS Study) and comparison with other models to predict operative mortality
Baré i Mañas, Marisa (Universitat Autònoma de Barcelona. Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva)
Alcántara Moral, Manuel Jesús (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Gil, Maria José (Parc de Salut Mar Cirurgia general i digestiva)
Collera, Pablo (Althaia Xarxa Assistencial Universitària de Manresa)
Pont, Marina (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Escobar, Antonio (Hospital Universitario Basurto)
Sarasqueta, Cristina (Instituto de Investigación Sanitaria Biodonostia)
Redondo, Maximino (Agencia Sanitaria Costa del Sol)
Briones, Eduardo (Unidad de Epidemiología. Distrito Sevilla, Servicio Andaluz de Salud)
Dujovne, Paula (Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Fundación Alcorcón)
Quintana, Jose Maria (Hospital Galdakao-Usansolo)
CARESS-CCR Study Group

Date: 2018
Abstract: Background: To validate and recalibrate the CR- POSSUM model and compared its discriminatory capacity with other European models such as POSSUM, P-POSSUM, AFC or IRCS to predict operative mortality in surgery for colorectal cancer. Methods: Prospective multicenter cohort study from 22 hospitals in Spain. We included patients undergoing planned or urgent surgery for primary invasive colorectal cancers between June 2010 and December 2012 (N= 2749). Clinical data were gathered through medical chart review. We validated and recalibrated the predictive models using logistic regression techniques. To calculate the discriminatory power of each model, we estimated the areas under the curve - AUC (95% CI). We also assessed the calibration of the models by applying the Hosmer-Lemeshow test. Results: In-hospital mortality was 1. 5% and 30-day mortality, 1. 7%. In the validation process, the discriminatory power of the CR-POSSUM for predicting in-hospital mortality was 73. 6%. However, in the recalibration process, the AUCs improved slightly: the CR-POSSUM reached 75. 5% (95% CI: 67. 3-83. 7). The discriminatory power of the CR-POSSUM for predicting 30-day mortality was 74. 2% (95% CI: 67. 1-81. 2) after recalibration; among the other models the POSSUM had the greatest discriminatory power, with an AUC of 77. 0% (95% CI: 68. 9-85. 2). The Hosmer-Lemeshow test showed good fit for all the recalibrated models. Conclusion: The CR-POSSUM and the other models showed moderate capacity to discriminate the risk of operative mortality in our context, where the actual operative mortality is low. Nevertheless the IRCS might better predict in-hospital mortality, with fewer variables, while the CR-POSSUM could be slightly better for predicting 30-day mortality.
Note: Altres ajuts: The Department of Health of the Basque Country (2010111098); KRONIKGUNE-Centro de Investigación en Cronicidad (KRONIK 11/006)
Note: Número d'acord de subvenció FIS/PS09/00314
Note: Número d'acord de subvenció FIS/PS09/00910
Note: Número d'acord de subvenció FIS/PS09/00746
Note: Número d'acord de subvenció FIS/PS09/00805
Note: Número d'acord de subvenció FIS/PI09/90460
Note: Número d'acord de subvenció FIS/PI09/90490
Note: Número d'acord de subvenció FIS/PI09/90397
Note: Número d'acord de subvenció FIS/PI09/90453
Note: Número d'acord de subvenció FIS/PI09/90441
Note: Número d'acord de subvenció ISCIII/RD12/0001/0007
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Operative mortality ; Colorectal cancer ; Predictive model ; Cr-possum
Published in: BMC health services research, 2018 , ISSN 1472-6963

DOI: 10.1186/s12913-018-2839-x
PMID: 29378647


10 p, 467.2 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles

 Record created 2018-02-01, last modified 2021-03-11



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