Web of Science: 128 citations, Scopus: 131 citations, Google Scholar: citations,
Safety and Efficacy of Solitaire Stent Thrombectomy
Campbell, Bruce C.V.
Hill, Michael D.
Rubiera, Marta
Menon, Bijoy K.
Demchuk, Andrew
Donnan, Geoffrey A.
Roy, Daniel
Thornton, John
Dorado Bouix, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bonafe, Alain
Levy, Elad I.
Diener, Hans-Christoph
Hernández-Pérez, María
Pereira, Vitor Mendes
Blasco, Jordi
Quesada, Helena
Rempel, Jeremy
Jahan, Reza
Davis, Stephen M.
Stouch, Bruce C.
Mitchell, Peter J.
Jovin, Tudor G.
Saver, Jeffrey L.
Goyal, Mayank
Universitat Autònoma de Barcelona

Date: 2016
Abstract: Supplemental Digital Content is available in the text. Patient-level data were pooled from trials in which the Solitaire was the only or the predominant device used in a prespecified meta-analysis (SEER Collaboration): Solitaire FR With the Intention for Thrombectomy as Primary Endovascular Treatment (SWIFT PRIME), Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times (ESCAPE), Extending the Time for Thrombolysis in Emergency Neurological Deficits-Intra-Arterial (EXTEND-IA), and Randomized Trial of Revascularization With Solitaire FR Device Versus Best Medical Therapy in the Treatment of Acute Stroke Due to Anterior Circulation Large Vessel Occlusion Presenting Within Eight Hours of Symptom Onset (REVASCAT). The primary outcome was ordinal analysis of modified Rankin Score at 90 days. The primary analysis included all patients in the 4 trials with 2 sensitivity analyses: (1) excluding patients in whom Solitaire was not the first device used and (2) including the 3 Solitaire-only trials (excluding ESCAPE). Secondary outcomes included functional independence (modified Rankin Score 0-2), symptomatic intracerebral hemorrhage, and mortality. The primary analysis included 787 patients: 401 randomized to endovascular thrombectomy and 386 to standard care, and 82. 6% received intravenous thrombolysis. The common odds ratio for modified Rankin Score improvement was 2. 7 (2. 0-3. 5) with no heterogeneity in effect by age, sex, baseline stroke severity, extent of computed tomography changes, site of occlusion, or pretreatment with alteplase. The number needed to treat to reduce disability was 2. 5 and for an extra patient to achieve independent outcome was 4. 25 (3. 29-5. 99). Successful revascularization occurred in 77% treated with Solitaire device. The rate of symptomatic intracerebral hemorrhage and overall mortality did not differ between treatment groups. Solitaire thrombectomy for large vessel ischemic stroke was safe and highly effective with substantially reduced disability. Benefits were consistent in all prespecified subgroups.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Endovascular treatment ; Intra-arterial therapy ; Ischemic stroke ; Mechanical thrombectomy ; Meta-analysis ; Randomized controlled trial ; Stent retriever device ; Thrombolysis
Published in: Stroke, Vol. 47 (february 2016) , p. 798-806, ISSN 1524-4628

DOI: 10.1161/STROKEAHA.115.012360
PMID: 26888532


9 p, 730.3 KB

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Articles > Research articles
Articles > Published articles

 Record created 2018-02-07, last modified 2021-05-12



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