Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer
Saus, Ester (Universitat Pompeu Fabra)
Brunet Vega, Anna (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Iraola-Guzmán, Susana (Universitat Pompeu Fabra)
Pegueroles, Cinta (Universitat Pompeu Fabra)
Gabaldón, Toni (Institució Catalana de Recerca i Estudis Avançats)
Pericay, Carles (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Universitat Autònoma de Barcelona

Date:	2016
Abstract:	Colorectal cancer (CRC) is the fourth most common cause of death worldwide. Surgery is usually the first line of treatment for patients with CRC but many tumors with similar histopathological features show significantly different clinical outcomes. The discovery of robust prognostic biomarkers in patients with CRC is imperative to achieve more effective treatment strategies and improve patient's care. Recent progress in next generation sequencing methods and transcriptome analysis has revealed that a much larger part of the genome is transcribed into RNA than previously assumed. Collectively referred to as non-coding RNAs (ncRNAs), some of these RNA molecules such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been shown to be altered and to play critical roles in tumor biology. This discovery leads to exciting possibilities for personalized cancer diagnosis, and therapy. Many lncRNAs are tissue and cancer-type specific and have already revealed to be useful as prognostic markers. In this review, we focus on recent findings concerning aberrant expression of lncRNAs in CRC tumors and emphasize their prognostic potential in CRC. Further studies focused on the mechanisms of action of lncRNAs will contribute to the development of novel biomarkers for diagnosis and disease progression.
Grants:	Ministerio de Economía y Competitividad SEV-2012-0208 Ministerio de Economía y Competitividad BIO2012-37161 European Commission 642095
Note:	Altres ajuts: The authors thank Jesse R. Willis for his help in editing the manuscript. TG group acknowledges support of the Spanish Ministry of Economy and Competitiveness grants, cofounded by European Regional Development Fund (ERDF); from the European Union and ERC Seventh Framework Programme (FP7/2007-2013) under grant agreement ERC-2012-StG-310325. CP group acknowledges support from the Fundació Parc Taulí by grants CIR2010040 and CIR2014023 (http://www.tauli.cat/tauli/en/Fpt/fpt.htm).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Ñong non-coding RNA ; NcRNA ; Prognostic marker ; Colorectal cancer ; Biomarker
Published in:	Frontiers in genetics, Vol. 7 (april 2016) , ISSN 1664-8021

DOI: 10.3389/fgene.2016.00054
PMID: 27148353

14 p, 648.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
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Articles > Published articles