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Pàgina inicial > Articles > Articles publicats > Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer |
Data: | 2016 |
Resum: | Colorectal cancer (CRC) is the fourth most common cause of death worldwide. Surgery is usually the first line of treatment for patients with CRC but many tumors with similar histopathological features show significantly different clinical outcomes. The discovery of robust prognostic biomarkers in patients with CRC is imperative to achieve more effective treatment strategies and improve patient's care. Recent progress in next generation sequencing methods and transcriptome analysis has revealed that a much larger part of the genome is transcribed into RNA than previously assumed. Collectively referred to as non-coding RNAs (ncRNAs), some of these RNA molecules such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been shown to be altered and to play critical roles in tumor biology. This discovery leads to exciting possibilities for personalized cancer diagnosis, and therapy. Many lncRNAs are tissue and cancer-type specific and have already revealed to be useful as prognostic markers. In this review, we focus on recent findings concerning aberrant expression of lncRNAs in CRC tumors and emphasize their prognostic potential in CRC. Further studies focused on the mechanisms of action of lncRNAs will contribute to the development of novel biomarkers for diagnosis and disease progression. |
Ajuts: | Ministerio de Economía y Competitividad SEV-2012-0208 Ministerio de Economía y Competitividad BIO2012-37161 European Commission 642095 |
Nota: | Altres ajuts: The authors thank Jesse R. Willis for his help in editing the manuscript. TG group acknowledges support of the Spanish Ministry of Economy and Competitiveness grants, cofounded by European Regional Development Fund (ERDF); from the European Union and ERC Seventh Framework Programme (FP7/2007-2013) under grant agreement ERC-2012-StG-310325. CP group acknowledges support from the Fundació Parc Taulí by grants CIR2010040 and CIR2014023 (http://www.tauli.cat/tauli/en/Fpt/fpt.htm). |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Ñong non-coding RNA ; NcRNA ; Prognostic marker ; Colorectal cancer ; Biomarker |
Publicat a: | Frontiers in genetics, Vol. 7 (april 2016) , ISSN 1664-8021 |
14 p, 648.4 KB |