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Neurophysiological evidence of impaired self-monitoring in schizotypal personality disorder and its reversal by dopaminergic antagonism
Rabella, Mireia (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Grasa, Eva (Institut d'Investigació Biomèdica Sant Pau)
Corripio, Iluminada (Institut d'Investigació Biomèdica Sant Pau)
Romero, Sergio (CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain)
Mañanas, Miquel Àngel (Barcelona College of Industrial Engineering (EUETIB), Universitat Politècnica de Catalunya (UPC), Barcelona 08028, Spain)
Antonijoan, Rosa Mª. (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Münte, Thomas F. (Institute of Psychology II, University of Lübeck, Germany)
Pérez, Víctor (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Riba, Jordi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Universitat Autònoma de Barcelona

Date: 2016
Abstract: Schizotypal personality disorder (SPD) is a schizophrenia-spectrum disorder characterized by odd or bizarre behavior, strange speech, magical thinking, unusual perceptual experiences, and social anhedonia. Schizophrenia proper has been associated with anomalies in dopaminergic neurotransmission and deficits in neurophysiological markers of self-monitoring, such as low amplitude in cognitive event-related brain potentials (ERPs) like the error-related negativity (ERN), and the error positivity (Pe). These components occur after performance errors, rely on adequate fronto-striatal function, and are sensitive to dopaminergic modulation. Here we postulated that analogous to observations in schizophrenia, SPD individuals would show deficits in self-monitoring, as measured by the ERN and the Pe. We also assessed the capacity of dopaminergic antagonists to reverse these postulated deficits. We recorded the electroencephalogram (EEG) from 9 SPD individuals and 12 healthy controls in two separate experimental sessions while they performed the Eriksen Flanker Task, a classical task recruiting behavioral monitoring. Participants received a placebo or 1 mg risperidone according to a double-blind randomized design. After placebo, SPD individuals showed slower reaction times to hits, longer correction times following errors and reduced ERN and Pe amplitudes. While risperidone impaired performance and decreased ERN and Pe in the control group, it led to behavioral improvements and ERN amplitude increases in the SPD individuals. These results indicate that SPD individuals show deficits in self-monitoring analogous to those in schizophrenia. These deficits can be evidenced by neurophysiological measures, suggest a dopaminergic imbalance, and can be reverted by dopaminergic antagonists.
Note: Altres ajuts: This study was funded by "Fundació La Marató de TV3", grant number: 0113310. The funding source had no role in study design, data collection and analysis, interpretation of results and preparation of the manuscript.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Schizotypal personality disorder ; Behavioral monitoring ; Neurophysiology ; Error-related negativity ; Dopaminergic antagonism
Published in: NeuroImage, Vol. 11 (june 2016) , p. 770-779, ISSN 2213-1582

DOI: 10.1016/j.nicl.2016.05.019
PMID: 27330977


10 p, 1.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació Biomèdica Sant Pau
Articles > Research articles
Articles > Published articles

 Record created 2018-02-07, last modified 2020-11-11



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