Web of Science: 37 cites, Scopus: 64 cites, Google Scholar: cites,
Impact of co-infections with enteric pathogens on children suffering from acute diarrhea in southwest China
Zhang, Shun-Xian Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, 200025 People's Republic of China
Zhou, Yong-Ming
Xu, Wen
Tian, Li-Guang
Chen, Jia-Xu
Chen, Shao-Hong
Dang, Zhi-Sheng
Gu, Wen-Peng
Yin, Jian-Wen
Serrano Ferron, Emmanuel (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Zhou, Xiao-Nong

Data: 2016
Resum: Acute diarrhea is a global health problem, resulting in high morbidity and mortality in children. It has been suggested that enteric pathogen co-infections play an important role in gastroenteritis, but most research efforts have only focused on a small range of species belonging to a few pathogen groups. This study aimed to assess the impact of co-infections with a broad range of enteric pathogens on children aged below five years who suffer from acute diarrhea in southwest China. A total of 1020 subjects (850 diarrhea cases and 170 healthy controls) were selected from four sentinel hospitals in Kunming, Yunnan province, southwest China, from June 2014 to July 2015. Stool specimens were collected to detect five virus (rotavirus group A, RVA; norovirus, NoV; Sapovirus, SaV; astrovirus, As; and adenovirus, Ad), seven bacterial (diarrheagenic Escherichia coli, DEC; non-typhoidal Salmonella, NTS; Shigella spp. ; Vibrio cholera ; Vibrio parahaemolyticus ; Aeromonas spp. ; and Plesiomonas spp. ), and three protozoan (Cryptosporidium spp. , Giardia lamblia, and Blastocystis hominis, B. hominis) species using standard microbiologic and molecular methods. Data were analyzed using the partial least square regression technique and chi-square test. At least one enteric pathogen was detected in 46. 7 % (n = 397) of acute gastroenteritis cases and 13. 5 % (n = 23) of healthy controls (χ 2 = 64. 4, P < 0. 05). Single infection with RVA was associated with acute diarrhea (26. 5 % vs. 5. 8 %, P < 0. 05). The prevalence of a single infection with B. hominis in diarrhea cases was higher than in healthy controls (3. 1 % vs. 0. 5 %, OR = 4. 7, 95 % CI : 1. 01-112. 0). Single infection with NoV GII was not associated with diarrhea (4. 4 % vs. 3. 5 %, OR = 1. 2, 95 % CI : 0. 5-3. 3). Single infections with bacterial species were not observed. The prevalence of co-infections with two enteric pathogens in diarrhea cases was higher than in asymptomatic children (20. 1 % vs. 5. 3 %, P < 0. 05). RVA-NoV GII was the most common co-infection in symptomatic children (4. 4 %), with it aggravating the severity of diarrhea. Although it is clear that RVA has an overwhelming impact on diarrhea illnesses in children, co-infection with other enteric pathogens appears to also aggravate diarrhea severity. These findings should serve as evidence for public health services when planning and developing intervention programs. The online version of this article (doi:10. 1186/s40249-016-0157-2) contains supplementary material, which is available to authorized users.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Co-infection ; Diarrhea ; Bacteria ; Virus ; Intestinal protozoa ; Children ; Severity ; Kunming ; Yunnan ; China
Publicat a: Infectious Diseases of Poverty, Vol. 5 (june 2016) , ISSN 2049-9957

DOI: 10.1186/s40249-016-0157-2
PMID: 27349521

13 p, 2.0 MB

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