L1CAM expression in endometrial carcinomas : an ENITEC collaboration study
van der Putten, Louis J. M. (Department of Obstetrics and Gynaecology, Radboud University Medical Center)
Visser, Nicole C. M. (Department of Pathology, Radboud University Medical Center)
van de Vijver, Koen (Department of Pathology, Anthoni van Leeuwenhoek Hospital)
Santacana, Maria (Institut de Recerca Biomèdica de Lleida)
Bronsert, Peter (Institute of Pathology, University Medical Center Freiburg)
Bulten, Johan (Department of Pathology, Radboud University Medical Center)
Hirschfeld, Marc (German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ))
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Garcia, Angel (Hospital Universitari Vall d'Hebron)
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya))
Alameda, Francesc (Hospital del Mar (Barcelona, Catalunya))
Trovik, Jone (Haukeland University Hospital (Bergen, Noruega))
Kopperud, Reidun K. (Center for Cancer Biomarkers (CCBIO), University of Bergen)
Huvila, Jutta (University of Turku. Department of Pathology)
Schrauwen, Stefanie (University Hospitals Gasthuisberg (Leuven, Bélgica))
Koskas, Martin (Department of Obstetrics and Gynecology, Bichat-Claude Bernard Hospital)
Walker, Francine (Department of Pathology, Bichat-Claude Bernard Hospital)
Weinberger, Vit (Department of Gynecology and Obstetrics, Faculty of Medicine, Masaryk University)
Minar, Lubos (Department of Gynecology and Obstetrics, Faculty of Medicine, Masaryk University)
Jandakova, Eva (Institute of Pathology, Faculty of Medicine, Masaryk University)
Snijders, Marc P. L. M. (Department of Obstetrics and Gynaecology, Canisius-Wilhelmina Hospital)
van den Berg-van Erp, Saskia (Department of Pathology, Canisius-Wilhelmina Hospital)
Matias-Guiu, Xavier (Institut de Recerca Biomèdica de Lleida)
Salvesen, Helga B. (Haukeland University Hospital (Bergen, Noruega))
Amant, Frederic (University Hospitals Gasthuisberg (Leuven, Bélgica))
Massuger, Leon FAG (Department of Obstetrics and Gynaecology, Radboud University Medical Center)
Pijnenborg, Johanna M. A. (Department of Obstetrics and Gynaecology, TweeSteden Hospital)
Universitat Autònoma de Barcelona

Fecha:	2016
Resumen:	Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic marker in stage I EECs, but less is known about L1CAM expression in advanced-stage EECs and NEECs. This study analyses L1CAM expression in a clinically representative cohort of endometrial carcinomas. The expression of L1CAM was immunohistochemically determined in 1199 endometrial carcinomas, treated at one of the European Network for Individualized Treatment of Endometrial Cancer (ENITEC) centres. Staining was considered positive when >10% of the tumour cells expressed L1CAM. The association between L1CAM expression and several clincopathological characteristics and disease outcome was calculated. In all, L1CAM was expressed in 10% of the 935 stage I EECs, 18% of the 160 advanced stage EECs, and 75% of the 104 NEECs. The expression of L1CAM was associated with advanced stage, nodal involvement, high tumour grade, non-endometrioid histology, lymphovascular space invasion, and distant recurrences in all cases, and with reduced survival in the EECs, but not in the NEECs. The expression of L1CAM is a strong predictor of poor outcome in EECs, but not NEECs. It is strongly associated with non-endometrioid histology and distant spread, and could improve the postoperative selection of high-risk endometrial carcinomas. The value of L1CAM expression in the preoperative selection of high-risk endometrial carcinomas should be studied.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Endometrial cancer ; Endometrioid ; Non-endometrioid ; L1CAM ; Immunohistochemistry
Publicado en:	British Journal of Cancer, Vol. 115 (08 2016) , p. 716-724, ISSN 1532-1827

DOI: 10.1038/bjc.2016.235
PMID: 27505134

9 p, 341.1 KB

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