Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea
Serrano Pariente, José (Sociedad Española de Neumología y Cirugía Torácica)
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau)
Soriano, Joan B.. (Universidad Autónoma de Madrid)
Mayos Pérez, Mercè (Institut d'Investigació Biomèdica Sant Pau)
López Viña, Antolín (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Picado Vallés, César (Universitat de Barcelona)
Vigil Giménez, Laura (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Universitat Autònoma de Barcelona

Date:	2017
Abstract:	Continuous positive airway pressure () in asthma patients with concomitant obstructive sleep apnea syndrome () seems to have a favorable impact on asthma, but data are inconsistent due to methodological limitations of previous studies. Prospective, multicenter study. We examined asthma outcomes after 6 months of in 99 adult asthma patients (mean age 57 years) with (respiratory disturbance index ≥20). Asthma control and quality of life were assessed with the Asthma Control Questionnaire () and the Mini Asthma Quality of Life Questionnaire (Mini), respectively. Data were analyzed by intention-to-treat basis. The mean ± score of the decreased from 1. 39 ± 0. 91 at baseline to 1. 0 ± 0. 78 at 6 months (P = 0. 003), the percentage of patients with uncontrolled asthma from 41. 4% to 17. 2% (P = 0. 006), and the percentage of patients with asthma attacks in the 6 months before and after treatment from 35. 4% to 17. 2% (P = 0. 015). The score of the increased from 5. 12 ± 1. 38 to 5. 63 ± 1. 17 (P = 0. 009). There were also significant improvements in symptoms of gastroesophageal reflux and rhinitis, bronchial reversibility, and exhaled nitric oxide values (all P < 0. 05). No significant changes were observed in drug therapy for asthma or their comorbidities nor in the patients' weight. Asthma control (both actual and future risk), quality of life, and lung function improved after starting continuous positive airway pressure in asthmatics with moderate to severe obstructive sleep apnea syndrome.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Asthma ; Bronchial hyperreactivity ; Continuous positive airway pressure ; Obstructive sleep apnea syndrome ; Quality of life
Published in:	Allergy, Vol. 72, Issue 5 (May 2017) , p. 802-812, ISSN 1398-9995

DOI: 10.1111/all.13070
PMID: 27732758

11 p, 327.8 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles