The role of prostate tumor overexpressed 1 in cancer progression
Cánovas, Verónica (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Lleonart, Matilde (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Morote Robles, Juan (Hospital Universitari Vall d'Hebron)
Paciucci, Rosanna (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Data:	2017
Resum:	Prostate-Tumor-Overexpressed-1 (PTOV1) is a conserved adaptor protein discovered as overexpressed in prostate cancer. Since its discovery, the number of binding partners and associated cellular functions has increased and helped to identify PTOV1 as regulator of gene expression at transcription and translation levels. Its overexpression is associated with increased tumor grade and proliferation in prostate cancer and other neoplasms, including breast, ovarian, nasopharyngeal, squamous laryngeal, hepatocellular and urothelial carcinomas. An important contribution to higher levels of PTOV1 in prostate tumors is given by the frequent rate of gene amplifications, also found in other tumor types. The recent resolution of the structure by NMR of the PTOV domain in PTOV2, also identified as Arc92/ACID1/MED25, has helped to shed light on the functions of PTOV1 as a transcription factor. In parallel, by studying its interaction with RACK1, we have discovered PTOV1 action in promoting mRNAs translation. Here, we will focus on the role of PTOV1 in cancer, re-examine its pro-oncogenic effects and re-evaluate the most relevant interactions and evidences of its cellular functions. The data are used to formulate a model for the mechanisms of action of PTOV1 in line with its recently described activities and cellular pathways modulated in cancer.
Ajuts:	Ministerio de Economía y Competitividad SAF2014/59958-R Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-733 Instituto de Salud Carlos III PI13-00173 Instituto de Salud Carlos III RD12-0036-0035
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	PTOV1 ; Cancer progression ; Prostate cancer ; Cancer stem cells ; Transcription
Publicat a:	Oncotarget, Vol. 8, Num. 7 (February 2017) , p. 12451-12471, ISSN 1949-2553

DOI: 10.18632/oncotarget.14104
PMID: 28029646

21 p, 4.5 MB

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