Consensus on the Definition of Advanced Parkinson's Disease : A Neurologists-Based Delphi Study (CEPA Study)
Luquin, Maria-Rosario (Clínica Universidad de Navarra)
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau)
Martinez-Martin, Pablo (Instituto de Salud Carlos III)
Mir, Pablo (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Tolosa, Eduardo S. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Universitat Autònoma de Barcelona

Date:	2017
Abstract:	To date, no consensus exists on the key factors for diagnosing advanced Parkinson disease (APD). To obtain consensus on the definition of APD, we performed a prospective, multicenter, Spanish nationwide, 3-round Delphi study (CEPA study). An ad hoc questionnaire was designed with 33 questions concerning the relevance of several clinical features for APD diagnosis. In the first-round, 240 neurologists of the Spanish Movement Disorders Group participated in the study. The results obtained were incorporated into the questionnaire and both, results and questionnaire, were sent out to and fulfilled by 26 experts in Movement Disorders. Review of results from the second-round led to a classification of symptoms as indicative of "definitive," "probable," and "possible" APD. This classification was confirmed by 149 previous participating neurologists in a third-round, where 92% completely or very much agreed with the classification. Definitive symptoms of APD included disability requiring help for the activities of daily living, presence of motor fluctuations with limitations to perform basic activities of daily living without help, severe dysphagia, recurrent falls, and dementia. These results will help neurologists to identify some key factors in APD diagnosis, thus allowing users to categorize the patients for a homogeneous recognition of this condition.
Note:	Altres ajuts: AbbVie Spain S.L.U., Avenida de Burgos, 91, 28050 Madrid, has given support to the Scientific Committee to finance meetings and group activities/logistics, without taking part in the design, collection of information, data analysis, or preparation of this manuscript.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Parkinson's disease ; Advanced Parkinson's disease
Published in:	Parkinson's Disease, Vol. 2017 (january 2017) , ISSN 2042-0080

DOI: 10.1155/2017/4047392
PMID: 28239501

8 p, 519.0 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles