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Prognostic impact of circulating plasma cells in patients with multiple myeloma : implications for plasma cell leukemia definition
Granell, Miquel (Institut d'Investigació Biomèdica Sant Pau)
Calvo, Xavier (Laboratory of Cytology. Department of Pathology, GRETNHE, IMIM Hospital del Mar Research Institute)
Garcia-Guiñón, Antoni (Department of Haematology, Hospital Universitari Arnau de Vilanova, Universitat de Lleida)
Escoda, Lourdes (Department of Haematology, Hospital Joan XXIII, Universitat Rovira i Virgili)
Abella, Eugènia (Department of Haematology. Hospital del Mar-IMIM, Universitat Autònoma de Barcelona)
Martínez, Clara Mª (Institut d'Investigació Biomèdica Sant Pau)
Teixidó, Montserrat (Department of Haematology, Hospital Universitari Arnau de Vilanova, Universitat de Lleida)
Gimenez, Mª Teresa (Department of Haematology, Hospital Joan XXIII, Universitat Rovira i Virgili)
Senín, Alicia (Department of Haematology. Hospital del Mar-IMIM, Universitat Autònoma de Barcelona)
Sanz, Patricia (Institut d'Investigació Biomèdica Sant Pau)
Campoy, Desirée (Department of Haematology, Hospital Universitari Arnau de Vilanova, Universitat de Lleida)
Vicent, Ana (Department of Haematology, Hospital Joan XXIII, Universitat Rovira i Virgili)
Arenillas, Leonor (Laboratory of Cytology. Department of Pathology, GRETNHE, IMIM Hospital del Mar Research Institute)
Rosiñol, Laura (Amyloidosis and Myeloma Unit, Department of Haematology, Hospital Clínic and IDIBAPS, Universitat de Barcelona)
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau)
Bladé, Joan (Amyloidosis and Myeloma Unit, Department of Haematology, Hospital Clínic and IDIBAPS, Universitat de Barcelona)
de Larrea, Carlos Fernández (Amyloidosis and Myeloma Unit, Department of Haematology, Hospital Clínic and IDIBAPS, Universitat de Barcelona)

Date: 2017
Abstract: The presence of circulating plasma cells in patients with multiple myeloma is considered a marker for highly proliferative disease. In the study herein, the impact of circulating plasma cells assessed by cytology on survival of patients with multiple myeloma was analyzed. Wright-Giemsa stained peripheral blood smears of 482 patients with newly diagnosed myeloma or plasma cell leukemia were reviewed and patients were classified into 4 categories according to the percentage of circulating plasma cells: 0%, 1-4%, 5-20%, and plasma cell leukemia with the following frequencies: 382 (79. 2%), 83 (17. 2%), 12 (2. 5%) and 5 (1. 0%), respectively. Median overall survival according to the circulating plasma cells group was 47, 50, 6 and 14 months, respectively. At multivariate analysis, the presence of 5 to 20% circulating plasma cells was associated with a worse overall survival (relative risk 4. 9, 95% CI 2. 6-9. 3) independently of age, creatinine, the Durie-Salmon system stage and the International Staging System (ISS) stage. Patients with ≥5% circulating plasma cells had lower platelet counts (median 86×10 9 /L vs. 214×10 9 /L, P <0. 0001) and higher bone marrow plasma cells (median 53% vs. 36%, P =0. 004). The presence of ≥5% circulating plasma cells in patients with multiple myeloma has a similar adverse prognostic impact as plasma cell leukemia.
Note: Número d'acord de subvenció AGAUR/2014/SGR-1281
Note: Número d'acord de subvenció AGAUR/2014/SGR-552
Note: Número d'acord de subvenció ISCII/RD12-0036-0071
Note: Número d'acord de subvenció ISCII/RD12-0036-0046
Note: Número d'acord de subvenció ISCII/PI16/00423
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Published in: Haematologica, Vol. 102 (june 2017) , p. 1099-1104, ISSN 1592-8721

PMID: 28255016
DOI: 10.3324/haematol.2016.158303


6 p, 408.9 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació Biomèdica Sant Pau
Articles > Research articles
Articles > Published articles

 Record created 2018-02-08, last modified 2020-02-08



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