Sex bias in diagnostic delay in bronchiectasis : An analysis of the Spanish Historical Registry of Bronchiectasis
Girón, Rosa Ma (Instituto de Investigación Hospital Universitario de la Princesa)
De Gracia, Javier (Hospital Universitari Vall d'Hebron)
Olveira, Casilda (Hospital Regional Universitario de Málaga)
Vendrell, Montserrat (Hospital Universitari de Girona Doctor Josep Trueta)
Martínez-García, Miguel Ángel (Hospital Universitari i Politècnic La Fe (València))
de la Rosa Carrillo, David (Hospital Plató (Barcelona, Catalunya))
Máiz, Luis (Hospital Universitario Ramón y Cajal (Madrid))
Ancochea, Julio (Instituto de Investigación Hospital Universitario de la Princesa)
Vázquez, Liliana (Instituto de Investigación Hospital Universitario de la Princesa)
Borderías, Luis (Hospital General Universitario San Jorge (Osca, Aragó))
Polverino, Eva (Hospital Clínic i Provincial de Barcelona)
Martínez-Moragón, Eva (Hospital Universitari Doctor Peset (València))
Rajas, Olga (Instituto de Investigación Hospital Universitario de la Princesa)
Soriano, Joan B.. (Instituto de Investigación Hospital Universitario de la Princesa)
Universitat Autònoma de Barcelona

Data:	2017
Resum:	Diagnostic delay is common in most respiratory diseases, particularly in bronchiectasis. However, sex bias in diagnostic delay has not been studied to date. Objective: Assessment of diagnostic delay in bronchiectasis by sex. Methods: The Spanish Historical Registry of Bronchiectasis recruited adults diagnosed with bronchiectasis from 2002 to 2011 in 36 centres in Spain. From a total of 2113 patients registered we studied 2099, of whom 1125 (53. 6%) were women. Results: No differences were found for sex or age (61. 0 ± 20. 6, p = 0. 88) or for localization of bronchiectasis (p = 0. 31). Bronchiectasis of unknown aetiology and secondary to asthma, childhood infections and tuberculosis was more common in women (all p s < 0. 05). More men than women were chronic obstructive pulmonary disease-related bronchiectasis and colonized by Haemophilus influenzae (p < 0. 001 for both). Onset of symptoms was earlier in women. The diagnostic delay for women with bronchiectasis was 2. 1 years more than for men (p = 0. 001). Discussion: We recorded a substantial delay in the diagnosis of bronchiectasis. This delay was significantly longer in women than in men (>2 years). Independent factors associated with this sex bias were age at onset of symptoms, smoking history, daily expectoration and reduced lung function.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Bronchiectasis ; Diagnostic delay ; Gender bias ; Gender gap ; Sex bias
Publicat a:	Chronic Respiratory Disease, Vol. 14 (april 2017) , p. 360-369, ISSN 1479-9731

DOI: 10.1177/1479972317702139
PMID: 28393532

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