Quantitative Evaluations of Time-Course and Treatment Effects of Systemic Agents for Psoriasis : A Model-Based Meta-Analysis
Checchio, T. (Pfizer Inc. (USA))
Ahadieh, S. (Pfizer Inc. (USA))
Gupta, Pankaj Kumar (Pfizer Inc. (USA))
Mandema, J. (Quantitative Solutions Inc. (USA))
Puig Sanz, Lluís. (Institut d'Investigació Biomèdica Sant Pau)
Wolk, R. (Pfizer Inc. (USA))
Valdez, H. (Pfizer Inc. (USA))
Tan, H. (Pfizer Inc. (USA))
Krishnaswami, S. (Pfizer Inc. (USA))
Tallman, A. (Pfizer Inc. (USA))
Kaur, M. (Pfizer Inc. (USA))
Ito, K. (Pfizer Inc. (USA))
Universitat Autònoma de Barcelona

Date:	2017
Abstract:	Aggregate data model-based meta-analysis is a regression approach to compare the dose-response and/or time-course across different treatments using summary level data from the literature. Literature search and systematic review following the Cochrane approach yielded 912 sources for investigational and approved treatments for psoriasis. In addition, data for tofacitinib were obtained from an internal database. Tofacitinib is an oral Janus kinase inhibitor. Two mathematical models were developed for Psoriasis Area and Severity Index (PASI) response in moderate to severe psoriasis patients to quantify the time to maximum effect for PASI75 and to evaluate the dose-response relationship for PASI responders (PASI50, PASI75, PASI90, PASI100) at Week 12. Body weight exhibited an inverse effect on the placebo component of both models, suggesting that body weight affects the overall PASI response regardless of drug. This analysis provides a quantitative framework for efficacy comparisons across psoriasis treatments.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Clinical Pharmacology and Therapeutics, Vol. 102, Num. 6 (December 2017) , p. 1006-1016, ISSN 1532-6535

DOI: 10.1002/cpt.732
PMID: 28480503

11 p, 860.0 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles