Non-Steroidal Anti-inflammatory Drugs As Host-Directed Therapy for Tuberculosis : A Systematic Review
Kroesen, Vera Marie (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Gröschel, Matthias I. (Department of Infectious Diseases, University Medical Center Groningen, University of Groningen)
Martinson, Neil (Perinatal HIV Research Unit, University of Witwatersrand)
Zumla, Alimuddin (Department of Microbiology, University College London Hospitals NHS Foundation Trust)
Maeurer, Markus (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine)
van der Werf, Tjip S. (Department of Infectious Diseases, University Medical Center Groningen, University of Groningen)
Vilaplana, Cristina (Institut Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Date:	2017
Abstract:	Lengthy, antimicrobial therapy targeting the pathogen is the mainstay of conventional tuberculosis treatment, complicated by emerging drug resistances. Host-directed therapies, including non-steroidal anti-inflammatory drugs (NSAIDs), in contrast, target host factors to mitigate disease severity. In the present Systematic Review, we investigate whether NSAIDs display any effects as therapy of TB and discuss possible mechanisms of action of NSAIDs as adjunctive therapy of TB. Ten studies, seven preclinical studies in mice and three clinical trials, were included and systematically reviewed. Our results point toward a beneficial effect of NSAIDs as adjunct to current TB therapy regimens, mediated by decreased lung pathology balancing host-immune reaction. The determination of the best timing for their administration in order to obtain the potential beneficial effects needs further investigation. Even if the preclinical evidence requires clinical evaluation, NSAIDs might represent a potential safe, simple, and cheap improvement in therapy of TB.
Grants:	Instituto de Salud Carlos III CP13-00174
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Non-steroidal anti-inflammatory drugs ; Host-directed therapies ; Tuberculosis ; Systematic review ; Infectious diseases
Published in:	Frontiers in immunology, Vol. 8 (june 2017) , ISSN 1664-3224

DOI: 10.3389/fimmu.2017.00772
PMID: 28713389

9 p, 608.4 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles