Web of Science: 2 citations, Scopus: 2 citations, Google Scholar: citations,
Predictive and Prognostic Brain Metastases Assessment in Luminal Breast Cancer Patients : FN14 and GRP94 from Diagnosis to Prophylaxis
Martínez-Aranda, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Hernández, Vanessa (Biological Clues of the Invasive and Metastatic Phenotype Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat)
Moreno, Ferran (Institut Germans Trias i Pujol)
Baixeras, Núria (Servei d'Anatomia Patològica, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat)
Cuadras, Daniel (Statistical Service, Sant Joan de Déu Research Foundation)
Urruticoechea, Ander (Institut Germans Trias i Pujol)
Gil-Gil, Miguel (Institut Germans Trias i Pujol)
Vidal, Noemí (Servei d'Anatomia Patològica, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat)
Andreu, Xavier (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Seguí, Miquel A. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Ballester, Rosa (Institut Germans Trias i Pujol)
Castella, Eva (Institut Germans Trias i Pujol)
Sierra, Angels (Faculty of Medicine, Universitat de VIC-Universitat Central de Catalunya)
Universitat Autònoma de Barcelona

Date: 2017
Abstract: FN14 has been implicated in many intracellular signaling pathways, and GRP94 is a well-known endoplasmic reticulum protein regulated by glucose. Recently, both have been associated with metastasis progression in breast cancer patients. We studied the usefulness of FN14 and GRP94 expression to stratify breast cancer patients according their risk of brain metastasis (BrM) progression. We analyzed FN14 and GRP94 by immunohistochemistry in a retrospective multicenter study using tissue microarrays from 208 patients with breast carcinomas, of whom 52 had developed BrM. Clinical and pathological characteristics and biomarkers expression in Luminal and non-Luminal patients were analyzed using a multivariate logistic regression model adjusted for covariates, and brain metastasis-free survival (BrMFS) was estimated using the Kaplan-Meier method and the Cox proportional hazards model. FN14 expression was associated with BrM progression mainly in Luminal breast cancer patients with a sensitivity (53. 85%) and specificity (89. 60%) similar to Her2 expression (46. 15 and 89. 84%, respectively). Moreover, the likelihood to develop BrM in FN14-positive Luminal carcinomas increased 36. 70-fold (3. 65-368. 25, p = 0. 002). Furthermore, the worst prognostic factor for BrMFS in patients with Luminal carcinomas was FN14 overexpression (HR = 8. 25; 95% CI: 2. 77-24. 61; p = 0. 00015). In these patients, GRP94 overexpression also increased the risk of BrM (HR = 3. 58; 95% CI: 0. 98-13. 11; p = 0. 054-Wald test). Therefore, FN14 expression in Luminal breast carcinomas is a predictive/prognostic biomarker of BrM, which combined with GRP94 predicts BrM progression in non-Luminal tumors 4. 04-fold (1. 19-8. 22, p = 0. 025), suggesting that both biomarkers are useful to stratify BrM risk at early diagnosis. We propose a new follow-up protocol for the early prevention of clinical BrM of breast cancer patients with BrM risk.
Note: info:eurepo/grantAgreement/MSCBS/FIS-PI14-00336
Note: info:eurepo/grantAgreement/ISCIII/2014 SGR 530
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Biomarkers ; Brain metastasis ; Breast cancer ; FN14 ; GRP94 ; Prediction ; Prevention ; Prognosis
Published in: Frontiers in Oncology, Vol. 7 (december 2017) , ISSN 2234-943X

DOI: 10.3389/fonc.2017.00283
PMID: 29250484


10 p, 637.1 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles

 Record created 2018-02-08, last modified 2020-11-01



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