Long-term Treatment with Low-Dose Caffeine Worsens BPSD-Like Profile in 3xTg-AD Mice Model of Alzheimer's Disease and Affects Mice with Normal Aging
Baeta Corral, Raquel (Universitat Autònoma de Barcelona. Institut de Neurociències)
Johansson, Björn (Karolinska University Hospital and Karolinska Institutet (Suècia))
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)

Fecha:	2018
Resumen:	Coffee or caffeine has recently been suggested as prophylaxis for dementia. Although memory problems are hallmarks of Alzheimer's disease, this dementia is also characterized by neuropsychiatric symptoms called Behavioral and Psychological Symptoms of Dementia (BPSD). The impact of preventive/therapeutic strategies on both cognitive and non-cognitive symptoms can be addressed in the 3xTg-AD mice, since they exhibit cognitive but also BPSD-like profiles. Here, we studied the long-term effects of a low dose of caffeine in male 3xTg-AD mice and as compared to age-matched non-transgenic (NTg) counterparts with normal aging. Animals were treated (water or caffeine in drinking water) from adulthood (6 months of age) until middle-aged (13 months of age), that in 3xTg-AD mice correspond to onset of cognitive impairment and advanced stages, respectively. The low caffeine dosing used (0. 3 mg/ml) was previously found to give a plasma concentration profile in mice roughly equivalent to that of a human coffee drinker. There were significant effects of caffeine on most behavioral variables, especially those related to neophobia and other anxiety-like behaviors, emotionality, and cognitive flexibility. The 3xTg-AD and NTg mice were differently influenced by caffeine. Overall, the increase of neophobia and other anxiety-related behaviors resulted in an exacerbation of BPSD-like profile in 3xTg-AD mice. Learning and memory, strongly influenced by anxiety in 3xTg-AD mice, got little benefit from caffeine, only shown after a detailed analysis of navigation strategies. The worsened pattern in NTg mice and the use of search strategies in 3xTg-AD mice make both groups more similar. Circadian motor activity showed genotype differences, which were found to be enhanced by caffeine. Selective effects of caffeine on NTg were found in the modulation of behaviors related to emotional profile and risk assessment. Caffeine normalized splenomegaly of 3xTg-AD mice, a physical indicator of their impaired peripheral immune system, and trended to increase their corticosterone levels. Our observations of adverse caffeine effects in an Alzheimer's disease model together with previous clinical observations suggest that an exacerbation of BPSD-like symptoms may partly interfere with the beneficial cognitive effects of caffeine. These results are relevant when coffee-derived new potential treatments for dementia are to be devised and tested.
Ayudas:	Instituto de Salud Carlos III PI10-00283 Agència de Gestió d'Ajuts Universitaris i de Recerca 2012FI_B1 00198
Nota:	Altres ajuts: BJ received support by the Åhlén Foundation and the Stockholm County Council (ALF 20170190). We thank Ismael Álvarez-Montón for his assistance in the chronic caffeine treatment. The animals used in the present study came from the colony of homozygous 3xTgAD and wild-type NTg mice established by Dr. LG-L at the Universitat Autònoma de Barcelona, Spain, from progenitors kindly provided by Prof. Frank M. LaFerla, Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, United States.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Aging ; Anxiety ; Memory ; NPS ; BPSD ; Circadian activity ; Translational ; Long-term effects
Publicado en:	Frontiers in Pharmacology, Vol. 9 (february 2018) , ISSN 1663-9812

DOI: 10.3389/fphar.2018.00079
PMID: 29497377

17 p, 4.1 MB

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