Post-Translational Modifications of H2A Histone Variants and Their Role in Cancer
Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)

Date:	2018
Abstract:	Histone variants are chromatin components that replace replication-coupled histones in a fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants represent the most numerous and diverse group among histone protein families. In the nucleosomal structure, H2A-H2B dimers can be removed and exchanged more easily than the stable H3-H4 core. The unstructured N-terminal histone tails of all histones, but also the C-terminal tails of H2A histones protrude out of the compact structure of the nucleosome core. These accessible tails are the preferential target sites for a large number of post-translational modifications (PTMs). While some PTMs are shared between replication-coupled H2A and H2A variants, many modifications are limited to a specific histone variant. The present review focuses on the H2A variants H2A. Z, H2A. X, and macroH2A, and summarizes their functions in chromatin and how these are linked to cancer development and progression. H2A. Z primarily acts as an oncogene and macroH2A and H2A. X as tumour suppressors. We further focus on the regulation by PTMs, which helps to understand a degree of context dependency.
Grants:	Ministerio de Economía y Competitividad BFU2015-66559-P European Commission 675610 Ministerio de Economía y Competitividad ISCIII/PIE16-00011 Ministerio de Educación, Cultura y Deporte FPU14-06542 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-305
Note:	Altres ajuts: Research leading to inventions at the IJC is supported by the 'La Caixa' Foundation, the Fundació Internacional Josep Carreras, Celgene Spain and the CERCA Programme/Generalitat de Catalunya.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Histone variants ; Post-translational modifications ; Cancer ; Epigenetics ; H2A.Z ; H2A.X ; MacroH2A
Published in:	Cancers, Vol. 10 (february 2018) , ISSN 2072-6694

DOI: 10.3390/cancers10030059
PMID: 29495465

25 p, 1.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
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Articles > Published articles